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Recent progress in the development of assays suited for histone deacetylase inhibitor screening.

Molecular Genetics and Metabolism

Acetylation, Antineoplastic Agents, chemical synthesis, pharmacology, Cells, Cultured, Drug Screening Assays, Antitumor, Enzyme Inhibitors, Fluorescent Dyes, Histone Deacetylase Inhibitors, Histone Deacetylases, metabolism, Humans, enzymology, Neoplasms, drug therapy

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      Abstract

      Histone deacetylase (HDAC) inhibitors have an unprecedented potential to occupy a major position in the future market of anticancer agents. However, progress in the development of these new chemotherapeutics is largely dependent on the existence of bioassays well-suited for inhibitor screening. Herein, we summarize recent developments in HDAC assay technology and, particularly, discuss different assay types with respect to their suitability for high-throughput screening programs.

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