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Tracing the Retrograde Route in Protein Trafficking
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Abstract
Retrograde transport, in which proteins and lipids are shuttled between endosomes
and biosynthetic/secretory compartments such as the Golgi apparatus, is crucial for
a diverse range of cellular functions. Mechanistic studies that explore the molecular
machinery involved in this retrograde trafficking route are shedding light on the
functions of transport proteins and are providing fresh insights into possible new
therapeutic directions.