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      Health care and societal costs of the management of children and adolescents with attention-deficit/hyperactivity disorder in Spain: a descriptive analysis

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          Abstract

          Background

          Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition in childhood (5.3% to 7.1% worldwide prevalence), with substantial overall financial burden to children/adolescents, their families, and society. The aims of this study were to describe the clinical characteristics of children and adolescents with ADHD in Spain, estimate the associated direct/indirect costs of the disorder, and assess whether the characteristics and financial costs differed between children/adolescents adequately responding to currently available pharmacotherapies compared with children/adolescents for whom pharmacotherapies failed.

          Methods

          This was a multicenter, cross-sectional, descriptive analysis conducted in 15 health units representative of the overall Spanish population. Data on demographic characteristics, socio-occupational status, social relationships, clinical variables of the disease, and pharmacological and non-pharmacological treatments received were collected in 321 children and adolescents with ADHD. Direct and indirect costs were estimated over one year from both a health care system and a societal perspective.

          Results

          The estimated average cost of ADHD per year per child/adolescent was €5733 in 2012 prices; direct costs accounted for 60.2% of the total costs (€3450). Support from a psychologist/educational psychologist represented 45.2% of direct costs and 27.2% of total costs. Pharmacotherapy accounted for 25.8% of direct costs and 15.5% of total costs. Among indirect costs (€2283), 65.2% was due to caregiver expenses. The total annual costs were significantly higher for children/adolescents who responded poorly to pharmacological treatment (€7654 versus €5517; P = 0.024), the difference being mainly due to significantly higher direct costs, particularly with larger expenses for non-pharmacological treatment ( P = 0.012).

          Conclusions

          ADHD has a significant personal, familial, and financial impact on the Spanish health system and society. Successful pharmacological intervention was associated with lower overall expenses in the management of the disorder.

          Electronic supplementary material

          The online version of this article (10.1186/s12888-017-1581-y) contains supplementary material, which is available to authorized users.

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          Most cited references43

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          Diagnostic and Statistical Manual of Mental Disorders

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            ADHD prevalence estimates across three decades: an updated systematic review and meta-regression analysis.

            Previous studies have identified significant variability in attention-deficit / hyperactivity disorder (ADHD) prevalence estimates worldwide, largely explained by methodological procedures. However, increasing rates of ADHD diagnosis and treatment throughout the past few decades have fuelled concerns about whether the true prevalence of the disorder has increased over time. We updated the two most comprehensive systematic reviews on ADHD prevalence available in the literature. Meta-regression analyses were conducted to test the effect of year of study in the context of both methodological variables that determined variability in ADHD prevalence (diagnostic criteria, impairment criterion and source of information), and the geographical location of studies. We identified 154 original studies and included 135 in the multivariate analysis. Methodological procedures investigated were significantly associated with heterogeneity of studies. Geographical location and year of study were not associated with variability in ADHD prevalence estimates. Confirming previous findings, variability in ADHD prevalence estimates is mostly explained by methodological characteristics of the studies. In the past three decades, there has been no evidence to suggest an increase in the number of children in the community who meet criteria for ADHD when standardized diagnostic procedures are followed.
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              The Validity and Reproducibility of a Work Productivity and Activity Impairment Instrument

              The construct validity of a quantitative work productivity and activity impairment (WPAI) measure of health outcomes was tested for use in clinical trials, along with its reproducibility when administered by 2 different methods. 106 employed individuals affected by a health problem were randomised to receive either 2 self-administered questionnaires (self administration) or one self-administered questionnaire followed by a telephone interview (interviewer administration). Construct validity of the WPAI measures of time missed from work, impairment of work and regular activities due to overall health and symptoms, were assessed relative to measures of general health perceptions, role (physical), role (emotional), pain, symptom severity and global measures of work and interference with regular activity. Multivariate linear regression models were used to explain the variance in work productivity and regular activity by validation measures. Data generated by interviewer-administration of the WPAI had higher construct validity and fewer omissions than that obtained by self-administration of the instrument. All measures of work productivity and activity impairment were positively correlated with measures which had proven construct validity. These validation measures explained 54 to 64% of variance (p less than 0.0001) in productivity and activity impairment variables of the WPAI. Overall work productivity (health and symptom) was significantly related to general health perceptions and the global measures of interference with regular activity. The self-administered questionnaire had adequate reproducibility but less construct validity than interviewer administration. Both administration methods of the WPAI warrant further evaluation as a measure of morbidity.
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                Author and article information

                Contributors
                fjquinterog@yahoo.es
                ramosquiroga@gmail.com
                jsansebastiancabases@gmail.com
                fmontanes@fhalcorcon.es
                AFERJAEN@telefonica.net
                martinez_josrag@gva.es
                mggiral@clinic.cat
                montserrat.graell@salud.madrid.org
                mjmardomingo@aepnya.net
                csoutullo@unav.es
                eirisjm@yahoo.es
                montsetellez22@gmail.com
                mpamias@tauli.cat
                jclauffer@yahoo.es
                jchueca-c@shire.com
                lgarciaorti@shire.com
                +34 93280400 , jalda@sjdhospitalbarcelona.org
                Journal
                BMC Psychiatry
                BMC Psychiatry
                BMC Psychiatry
                BioMed Central (London )
                1471-244X
                8 February 2018
                8 February 2018
                2018
                : 18
                : 40
                Affiliations
                [1 ]ISNI 0000 0001 2157 7667, GRID grid.4795.f, Psychiatry Department, Hospital Universitario Infanta Leonor and Psychiatry and Medical Psychology Department, , Complutense University, ; Madrid, Spain
                [2 ]GRID grid.7080.f, Department of Psychiatry, Hospital Universitari Vall d’Hebron, Barcelona, Spain; Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Spain; and Department of Psychiatry and Legal Medicine, , Universitat Autònoma de Barcelona, ; Bellaterra, Spain
                [3 ]ISNI 0000 0004 1937 0239, GRID grid.7159.a, Child and Adolescent Psychiatry Department, Hospital Universitario Ramón y Cajal, Madrid, Spain and Psychiatry Department, , Universidad de Alcalá, ; Madrid, Spain
                [4 ]ISNI 0000 0001 2206 5938, GRID grid.28479.30, Hospital Universitario Fundación de Alcorcón, Madrid, , Spain and Rey Juan Carlos I University, ; Madrid, Spain
                [5 ]GRID grid.488466.0, Department of Neuropediatrics, , Hospital Universitario Quirón, ; Madrid, Spain
                [6 ]ISNI 0000 0004 1770 9825, GRID grid.411289.7, UDPyPC, , Hospital Universitario Dr. Peset and University of Valencia and University CEU-UCH, ; Valencia, Spain
                [7 ]ISNI 0000 0000 9635 9413, GRID grid.410458.c, Child and Adolescent Psychiatry and Psychology Department, , Institute of Neuroscience, Hospital Clinic, ; Barcelona, Spain
                [8 ]ISNI 0000 0004 1767 5442, GRID grid.411107.2, Child and Adolescent Psychiatry and Psychology Department, , Hospital Infantil Universitario Niño Jesús and Biomedical Network Research Centre on Mental Health (CIBERSAM), ; Madrid, Spain
                [9 ]ISNI 0000 0001 2157 7667, GRID grid.4795.f, Child and Adolescent Psychiatry Department, Hospital Gregorio Marañón, , Universidad Complutense, ; Madrid, Spain
                [10 ]ISNI 0000 0001 2191 685X, GRID grid.411730.0, Child and Adolescent Psychiatry Unit, Department of Psychiatry and Medical Psychology, , University of Navarra Clinic, ; Pamplona, Spain
                [11 ]ISNI 0000 0000 8816 6945, GRID grid.411048.8, Neuropediatric Division, Pediatric Department, , Complejo Hospitalario Universitario Santiago De Compostela, ; Santiago de Compostela, Spain
                [12 ]ISNI 0000 0001 0360 9602, GRID grid.84393.35, Department of Neuropediatrics, Hospital La Fe, ; Valencia, Spain
                [13 ]Hospital Parc Taulí, Sabadell, Spain and Autonomous University of Barcelona, Bellaterra, Spain
                [14 ]Psychiatry and Mental Health Department, Hospital Universitario del Henares, Francisco de Victoria University, Madrid, Spain
                [15 ]Shire, Madrid, Spain
                [16 ]ISNI 0000 0001 0663 8628, GRID grid.411160.3, Child and Adolescent Psychiatry and Psychology Department, , Hospital Sant Joan de Déu, Esplugues de Llobregat, ; 08950 Barcelona, Spain
                Article
                1581
                10.1186/s12888-017-1581-y
                5806309
                29422022
                eefa3356-9e10-40e8-b398-9c53329dc8b0
                © The Author(s). 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 10 March 2017
                : 14 December 2017
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/100007343, Shire;
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2018

                Clinical Psychology & Psychiatry
                adhd,adolescence,school children,economic evaluation
                Clinical Psychology & Psychiatry
                adhd, adolescence, school children, economic evaluation

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