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5-aminolaevulinic acid (ALA), enhances heme oxygenase (HO)-1 expression and attenuates tubulointerstitial fibrosis and renal apoptosis in chronic cyclosporine nephropathy
Chi Liu ,
Ping Zhu ,
Masayuki Fujino ,
Yoshitaka Isaka ,
Hidenori Ito ,
Kiwamu Takahashi ,
Motowo Nakajima ,
Tohru Tanaka ,
Jian Zhuang ,
Xiao-Kang Li
December 2018
December 2018
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Abstract
Cyclosporine-A (CsA) is an immunosuppressant indicated for various immunological diseases;
however, it can induce chronic kidney injury. Oxidative stress and apoptosis play
a crucial role in CsA-induced nephrotoxicity. The present study evaluated the protective
effect of combining 5-aminolaevulinic acid with iron (5-ALA/SFC), a precursor of heme
synthesis, to enhance HO-1 activity against CsA-induced chronic nephrotoxicity.