Realistic simulation of reduced-dose CT with noise modeling and sinogram synthesis using DICOM CT images : Realistic simulation of reduced-dose CT using DICOM CT images

To develop an easily-implemented technique with free publicly-available analysis software to measure the modulation transfer function (MTF) and noise-power spectrum (NPS) of a clinical computed tomography (CT) system from images acquired using a widely-available and standardized American College of Radiology (ACR) CT accreditation phantom.

Dose reduction efforts in diagnostic CT have brought the tradeoff of dose versus image quality to the forefront. The need for meaningful characterization of image noise beyond that offered by pixel standard deviation is becoming increasingly important. This work aims to study the implementation of the noise power spectrum (NPS) and noise equivalent quanta (NEQ) on modern, multislice diagnostic CT scanners. The details of NPS and NEQ measurement are outlined and special attention is paid to issues unique to multislice CT. Aliasing, filter design and effects of acquisition geometry are investigated. While it was found that both metrics can be implemented in modern CT, it was discovered that NEQ cannot be aptly applied with certain non-traditional reconstruction filters or in helical mode. NPS and NEQ under a variety of conditions are examined. Extensions of NPS and NEQ to uses in protocol standardization are also discussed.

The accurate determination of x-ray signal properties is important to several computed tomography (CT) research and development areas, notably for statistical reconstruction algorithms and dose-reduction simulation. The most commonly used model of CT signal formation, assuming monoenergetic x-ray sources with quantum counting detectors obeying simple Poisson statistics, does not reflect the actual physics of CT acquisition. This paper describes a more accurate model, taking into account the energy-integrating detection process, nonuniform flux profiles, and data-conditioning processes. Methods are developed to experimentally measure and theoretically calculate statistical distributions, as well as techniques to analyze CT signal properties. Results indicate the limitations of current models and suggest improvements for the description of CT signal properties.