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      Effect of Histamine on Gene Expression and Release of Proopiomelanocortin-Derived Peptides from the Anterior and Intermediate Pituitary Lobes in Conscious Male Rats

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          Abstract

          Via activation of H<sub>1</sub> or H<sub>2</sub> receptors histamine (HA) stimulates the secretion of proopiomelanocortin (POMC)-derived peptides from the anterior (AL) and intermediate (IL) pituitary lobes of male rats. During selective inhibition of the AL or IL by pretreatment with dexamethasone (Dx) or bromocriptine (Br), respectively, we studied the effect of equipotent doses of intracerebroventricularly infused HA, the H<sub>1</sub>-receptor agonist 2-thiazolylethylamine (2TEA) or the H<sub>2</sub>-receptor agonist 4-methylHA (4MeHA) on the release of ACTH, β-endor-phin (β-END) immunoreactivity (ir) and α-melanocyte-stimulating hormone (α-MSH) in conscious male rats. Dx blocked the ACTH responses whereas Br prevented the α-MSH responses. Dx and Br equally inhibited the response of β-ENDir to HA and 4MeHA (80 and 70%, respectively). In contrast, the β-ENDir response to 2TEA was totally blocked by Dx but only inhibited 50% by Br. The inhibitory effect of Dx on the β-ENDir response to 2TEA was significantly stronger than the effect on the responses to HA and 4MeHA. POMC mRNA in the AL but not in the IL was increased almost 45% by HA and 2TEA and 20% by 4MeHA. Since all three histaminergic compounds in the doses used stimulated the release of β-ENDir equipotently, the results indicate that H<sub>1</sub>-receptor activation predominantly affects the release and synthesis of β-ENDir from the AL while H<sub>1</sub>-receptor activation affects the release of β-ENDir equally from the two lobes and only to some extent increases the synthesis in the AL. Thus, the findings suggest a differential involvement of H<sub>1</sub> and H<sub>2</sub> receptors in the mediation of the HA-induced effect on POMC-derived peptides in the AL and IL.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1995
          1995
          09 April 2008
          : 62
          : 4
          : 319-325
          Affiliations
          aDepartment of Medical Physiology, Division of Endocrinology and Metabolism, and bDepartment of Anatomy, The Panum Institute, and cDepartment of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Denmark
          Article
          127020 Neuroendocrinology 1995;62:319–325
          10.1159/000127020
          8544944
          © 1995 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Proopiomelanocortin and Corticotropin Regulation

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