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      Engineering Aspects of Enzymatic Signal Transduction: Photoreceptors in the Retina

      , , ,
      Biophysical Journal
      Elsevier BV

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          Abstract

          Identifying the basic module of enzymatic amplification as an irreversible cycle of messenger activation/deactivation by a "push-pull" pair of opposing enzymes, we analyze it in terms of gain, bandwidth, noise, and power consumption. The enzymatic signal transduction cascade is viewed as an information channel, the design of which is governed by the statistical properties of the input and the noise and dynamic range constraints of the output. With the example of vertebrate phototransduction cascade we demonstrate that all of the relevant engineering parameters are controlled by enzyme concentrations and, from functional considerations, derive bounds on the required protein numbers. Conversely, the ability of enzymatic networks to change their response characteristics by varying only the abundance of different enzymes illustrates how functional diversity may be built from nearly conserved molecular components.

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          Author and article information

          Journal
          Biophysical Journal
          Biophysical Journal
          Elsevier BV
          00063495
          December 2000
          December 2000
          : 79
          : 6
          : 2801-2817
          Article
          10.1016/S0006-3495(00)76519-2
          1301161
          11106590
          ef394ce4-ad53-4b34-866b-68fce88e1f0b
          © 2000

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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