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      Validity and reliability of the Physical Activity Questionnaire for Children (PAQ-C) and Adolescents (PAQ-A) in individuals with congenital heart disease

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          Abstract

          Objective

          To assess the criterion validity, internal consistency, reliability and cut-point for the Physical Activity Questionnaire for Children (PAQ-C) and Adolescents (PAQ-A) in children and adolescents with congenital heart disease–a special population at high cardiovascular risk in whom physical activity has not been extensively evaluated.

          Methods

          We included 84 participants (13.6±2.9 yrs, 50% female) with simple (37%), moderate (31%), or severe congenital heart disease (27%), as well as cardiac transplant recipients (6%), from BC Children’s Hospital, Canada. They completed the PAQ-C (≤11yrs, n = 28) or–A (≥12yrs, n = 56), and also wore a triaxial accelerometer (GT3X+ or GT9X) over the right hip for 7 days ( n = 59 met valid wear time criteria).

          Results

          Median daily moderate-to-vigorous physical activity was 46.9 minutes per day (IQR 31.6–61.8) and 25% met physical activity guidelines defined as ≥60 minutes of moderate-to-vigorous physical activity per day. Median PAQ-score was 2.6 (IQR 1.9–3.0). PAQ-Scores were significantly related to accelerometry-derived metrics of physical activity ( rho = 0.44–0.55, all p<0.01) and sedentary behaviour ( rho = -0.53, p<0.001). Internal consistency was high (α = 0.837), as was reliability (stability) of PAQ-Scores over a 4-months period (ICC = 0.73, 95%CI 0.55–0.84; p<0.001). We identified that a PAQ-Score cut-point of 2.87 discriminates between those meeting physical guidelines and those that do not in the combined PAQ-C and–A samples (area under the curve = 0.80 (95%CI 0.67–0.92).

          Conclusion

          Validity and reliability of the PAQ in children and adolescents with CHD was comparable to or stronger than previous studies in healthy children. Therefore, the PAQ may be used to estimate general levels of physical activity in children and adolescents with CHD.

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          Most cited references25

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          Understanding diagnostic tests 3: Receiver operating characteristic curves.

          The results of many clinical tests are quantitative and are provided on a continuous scale. To help decide the presence or absence of disease, a cut-off point for 'normal' or 'abnormal' is chosen. The sensitivity and specificity of a test vary according to the level that is chosen as the cut-off point. The receiver operating characteristic (ROC) curve, a graphical technique for describing and comparing the accuracy of diagnostic tests, is obtained by plotting the sensitivity of a test on the y axis against 1-specificity on the x axis. Two methods commonly used to establish the optimal cut-off point include the point on the ROC curve closest to (0, 1) and the Youden index. The area under the ROC curve provides a measure of the overall performance of a diagnostic test. In this paper, the author explains how the ROC curve can be used to select optimal cut-off points for a test result, to assess the diagnostic accuracy of a test, and to compare the usefulness of tests. The ROC curve is obtained by calculating the sensitivity and specificity of a test at every possible cut-off point, and plotting sensitivity against 1-specificity. The curve may be used to select optimal cut-off values for a test result, to assess the diagnostic accuracy of a test, and to compare the usefulness of different tests.
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            Congenital heart disease in the general population: changing prevalence and age distribution.

            Empirical data on the changing epidemiology of congenital heart disease (CHD) are scant. We determined the prevalence, age distribution, and proportion of adults and children with severe and other forms of CHD in the general population from 1985 to 2000. Where healthcare access is universal, we used administrative databases that systematically recorded all diagnoses and claims. Diagnostic codes conformed to the International Classification of Disease, ninth revision. Severe CHD was defined as tetralogy of Fallot, truncus arteriosus, transposition complexes, endocardial cushion defects, and univentricular heart. Prevalence of severe and other CHD lesions was determined in 1985, 1990, 1995, and 2000 using population numbers in Quebec. Children were subjects <18 years of age. The prevalence was 4.09 per 1000 adults in the year 2000 for all CHD and 0.38 per 1000 (9%) for those with severe lesions. Female subjects accounted for 57% of the adult CHD population. The median age of all patients with severe CHD was 11 years (interquartile range, 4 to 22 years) in 1985 and 17 years (interquartile range, 10 to 28 years) in 2000 (P<0.0001). The prevalence of severe CHD increased from 1985 to 2000, but the increase in adults was significantly higher than that observed in children. In the year 2000, 49% of those alive with severe CHD were adults. The prevalence in adults and median age of patients with severe CHD increased in the general population from 1985 to 2000. In 2000, there were nearly equal numbers of adults and children with severe CHD.
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              Lifetime prevalence of congenital heart disease in the general population from 2000 to 2010.

              Our objective was to obtain contemporary lifetime estimates of congenital heart disease (CHD) prevalence using population-based data sources up to year 2010.
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                26 April 2017
                2017
                : 12
                : 4
                : e0175806
                Affiliations
                [1 ]Children’s Heart Centre, BC Children’s Hospital, Vancouver BC, Canada
                [2 ]Department of Pediatrics, University of British Columbia, Vancouver BC, Canada
                Vanderbilt University, UNITED STATES
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                • Conceptualization: CV.

                • Data curation: CV.

                • Formal analysis: CV.

                • Funding acquisition: KCH.

                • Investigation: PHD RFG SLD.

                • Methodology: CV.

                • Project administration: CV.

                • Resources: KCH.

                • Visualization: CV.

                • Writing – original draft: CV.

                • Writing – review & editing: CV PHD RFG SLD KCH.

                Author information
                http://orcid.org/0000-0003-3811-2465
                Article
                PONE-D-16-28116
                10.1371/journal.pone.0175806
                5406026
                28445485
                ef462c63-20d0-462e-8828-920d867a5653
                © 2017 Voss et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 14 July 2016
                : 31 March 2017
                Page count
                Figures: 3, Tables: 2, Pages: 15
                Funding
                Funded by: Heart and Stroke Foundation of Canada, BC & Yukon Division
                Award ID: F1504
                Award Recipient :
                We received funding form the Heart and Stroke Foundation of Canada, BC & Yukon division (F1504; PI Harris) to support the ongoing research project from which the current data were drawn. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Medicine and Health Sciences
                Public and Occupational Health
                Physical Activity
                People and Places
                Population Groupings
                Age Groups
                Adolescents
                Research and Analysis Methods
                Research Assessment
                Research Validity
                Research and Analysis Methods
                Research Design
                Survey Research
                Questionnaires
                People and Places
                Population Groupings
                Age Groups
                Children
                People and Places
                Population Groupings
                Families
                Children
                Engineering and Technology
                Electronics
                Accelerometers
                Medicine and Health Sciences
                Pediatrics
                Child Health
                Medicine and Health Sciences
                Public and Occupational Health
                Child Health
                Medicine and Health Sciences
                Congenital Disorders
                Birth Defects
                Congenital Heart Defects
                Biology and Life Sciences
                Developmental Biology
                Morphogenesis
                Birth Defects
                Congenital Heart Defects
                Medicine and Health Sciences
                Cardiology
                Congenital Heart Defects
                Custom metadata
                Public sharing of data is restricted in order to preserve the confidentiality of the patients in this study, which is in accordance with The University of British Columbia/Children’s and Women’s Health Centre of British Columbia Research Ethics Board (UBC C&W REB) policy. Data will be available upon request to interested researchers. The Ethics Board is not responsible for data inquiries, so readers may contact Dr. Kevin Harris ( kharris2@ 123456cw.bc.ca ) to request the data.

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                Uncategorized

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