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      18F-fluorodeoxyglucose-PET and 99mTc-bicisate-SPECT in Creutzfeldt-Jakob disease.

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          Abstract

          In a patient with the occipitoparietal form of Creutzfeldt-Jakob disease (CJD) (Heidenhain type) positron emission tomography (PET) demonstrated decreased glucose utilization in the occipital lobes and adjacent cortical regions. Single photon emission computed tomography (SPECT) with 99mTc-bicisate showed a "coupled" decrease in blood flow in identical cortical areas in this patient. In contrast, magnetic resonance imaging (MRI) was normal. In the early stage of CJD, when still no major morphological abnormalities can be observed, functional imaging is useful for differential diagnosis, particularly to exclude other causes of dementia or pathological EEG patterns.

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          Author and article information

          Journal
          Ann Nucl Med
          Annals of nuclear medicine
          0914-7187
          0914-7187
          Feb 1996
          : 10
          : 1
          Affiliations
          [1 ] Department of Nuclear Medicine, University of Bonn, Germany.
          Article
          8814717
          ef4b1c53-f7d7-43e8-a7d6-304c0c01df7f
          History

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