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      Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial.

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          Abstract

          The relative efficacy of the addition of induction chemotherapy to chemoradiotherapy compared with chemoradiotherapy alone for patients with head and neck cancer is unclear. The PARADIGM study is a multicentre open-label phase 3 study comparing the use of docetaxel, cisplatin, and fluorouracil (TPF) induction chemotherapy followed by concurrent chemoradiotherapy with cisplatin-based concurrent chemoradiotherapy alone in patients with locally advanced head and neck cancer.

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          Author and article information

          Journal
          Lancet Oncol.
          The Lancet. Oncology
          Elsevier BV
          1474-5488
          1470-2045
          Mar 2013
          : 14
          : 3
          Affiliations
          [1 ] Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. robert_haddad@dfci.harvard.edu
          Article
          S1470-2045(13)70011-1
          10.1016/S1470-2045(13)70011-1
          23414589
          ef4bbbff-932b-407c-b765-0dcca08c18cb
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