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      Molecular signatures of natural selection.

      Annual review of genetics

      Animals, Genetics, Population, Genomics, Humans, Models, Statistical, Selection, Genetic

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          Abstract

          There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may provide important functional information. This review provides a nonmathematical description of the issues involved in detecting selection from DNA sequences and SNP data and is intended for readers who are not familiar with population genetic theory. Particular attention is placed on issues relating to the analysis of large-scale genomic data sets.

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          Journal
          16285858
          10.1146/annurev.genet.39.073003.112420

          Chemistry

          Animals, Genetics, Population, Genomics, Humans, Models, Statistical, Selection, Genetic

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