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      Decreased brown adipose tissue thermogenic activity following a reduction in brain serotonin by intraventricular p-chlorophenylalanine.

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      Bioscience reports

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          Abstract

          The effects of reducing brain serotonin (5-HT) levels by means of intracerebral-ventricular injections of the tryptophan antagonist p-chlorophenylalanine (PCPA) were investigated in male rats. Six days after the operation, PCPA-treated rats, either fed ad libitum or pair-fed to the food intake of control rats, showed decreased thermogenic activity and capacity in their interscapular brown adipose tissue (BAT) and also increased fat storage in their white adipose tissue (WAT). These results indicate that serotonergic synapses might play a regulatory role in the sympathetic control of BAT thermogenesis and in the rate of WAT deposition (by an as yet unidentified mechanism), in addition to their well established role in controlling food intake.

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          Author and article information

          Journal
          Biosci. Rep.
          Bioscience reports
          0144-8463
          0144-8463
          Feb 1987
          : 7
          : 2
          Affiliations
          [1 ] MRC Dunn Nutrition Unit, Cambridge.
          Article
          2443195
          ef5a7b38-219b-45af-83e6-4bd967ad0692
          History

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