Renal impairment is a potent risk factor for stroke, which remains a leading cause
of death and disability. Thrombolysis for acute ischemic stroke has transformed patient
outcomes, although the safety and efficacy of this approach remain poorly characterized
in patients with renal dysfunction, who manifest a higher risk of bleeding due to
uremia. We therefore examined the impact of renal impairment on clinical outcomes
with thrombolysis within the current 4.5-hour therapeutic window.