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Renal impairment reduces the efficacy of thrombolytic therapy in acute ischemic stroke.

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      Abstract

      Renal impairment is a potent risk factor for stroke, which remains a leading cause of death and disability. Thrombolysis for acute ischemic stroke has transformed patient outcomes, although the safety and efficacy of this approach remain poorly characterized in patients with renal dysfunction, who manifest a higher risk of bleeding due to uremia. We therefore examined the impact of renal impairment on clinical outcomes with thrombolysis within the current 4.5-hour therapeutic window.

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      Affiliations
      [1 ] Imperial Renal and Transplant Center, Imperial College Healthcare NHS Trust, London, UK. albert.power@nhs.net
      Journal
      Cerebrovasc. Dis.
      Cerebrovascular diseases (Basel, Switzerland)
      1421-9786
      1015-9770
      2013
      : 35
      : 1
      23428996
      000345071
      10.1159/000345071
      Copyright © 2013 S. Karger AG, Basel.

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