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      How glycogen sustains brain function: A plausible allosteric signaling pathway mediated by glucose phosphates

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          Abstract

          Astrocytic glycogen is the sole glucose reserve of the brain. Both glycogen and glucose are necessary for basic neurophysiology and in turn for higher brain functions. In spite of low concentration, turnover and stimulation-induced degradation, any interference with normal glycogen metabolism in the brain severely affects neuronal excitability and disrupts memory formation. Here, I briefly discuss the glycogenolysis-induced glucose-sparing effect, which involves glucose phosphates as key allosteric effectors in the modulation of astrocytic and neuronal glucose uptake and phosphorylation. I further advance a novel and thus far unexplored effect of glycogenolysis that might be mediated by glucose phosphates.

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          Author and article information

          Journal
          J Cereb Blood Flow Metab
          J. Cereb. Blood Flow Metab
          JCB
          spjcb
          Journal of Cerebral Blood Flow & Metabolism
          SAGE Publications (Sage UK: London, England )
          0271-678X
          1559-7016
          17 June 2019
          August 2019
          : 39
          : 8
          : 1452-1459
          Affiliations
          Independent Researcher, Rome, Italy
          Author notes
          Mauro DiNuzzo, Independent Researcher, Via Colle Formica 63, Velletri 00049, Rome, Italy. Email: mauro.dinuzzo@ 123456neuroenergetics.org
          Article
          PMC6681540 PMC6681540 6681540 10.1177_0271678X19856713
          10.1177/0271678X19856713
          6681540
          31208240
          © The Author(s) 2019
          Categories
          Brief Opinion

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