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      Exploiting multimode waveguides for pure fibre-based imaging

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      a , 1 , 2
      Nature Communications
      Nature Pub. Group

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          Abstract

          There has been an immense drive in modern microscopy towards miniaturization and fibre-based technology. This has been necessitated by the need to access hostile or difficult environments in situ and in vivo. Strategies to date have included the use of specialist fibres and miniaturized scanning systems accompanied by ingenious microfabricated lenses. Here we present a novel approach for this field by utilizing disordered light within a standard multimode optical fibre for lensless microscopy and optical mode conversion. We demonstrate the modalities of bright- and dark-field imaging and scanning fluorescence microscopy at acquisition rates that allow observation of dynamic processes such as Brownian motion of mesoscopic particles. Furthermore, we show how such control can realize a new form of mode converter and generate various types of advanced light fields such as propagation-invariant beams and optical vortices. These may be useful for future fibre-based implementations of super-resolution or light-sheet microscopy.

          Abstract

          Fibre-based technologies provide miniaturization, flexibility and the capability to access hard to reach areas. Čižmár and Dholakia exploit disorder in multimode fibres to enable a variety of imaging modalities, including bright- and dark-field microscopy and fluorescent imaging, using a single waveguide.

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          Most cited references20

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          Focusing coherent light through opaque strongly scattering media.

          We report focusing of coherent light through opaque scattering materials by control of the incident wavefront. The multiply scattered light forms a focus with a brightness that is up to a factor of 1000 higher than the brightness of the normal diffuse transmission.
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            Measuring the Transmission Matrix in Optics : An Approach to the Study and Control of Light Propagation in Disordered Media

            We introduce a method to experimentally measure the monochromatic transmission matrix of a complex medium in optics. This method is based on a spatial phase modulator together with a full-field interferometric measurement on a camera. We determine the transmission matrix of a thick random scattering sample. We show that this matrix exhibits statistical properties in good agreement with random matrix theory and allows light focusing and imaging through the random medium. This method might give important insights into the mesoscopic properties of complex medium.
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              Shaping the light transmission through a multimode optical fibre: complex transformation analysis and applications in biophotonics.

              We present a powerful approach towards full understanding of laser light propagation through multimode optical fibres and control of the light at the fibre output. Transmission of light within a multimode fibre introduces randomization of laser beam amplitude, phase and polarization. We discuss the importance of each of these factors and introduce an experimental geometry allowing full analysis of the light transmission through the multimode fibre and subsequent beam-shaping using a single spatial light modulator. We show that using this approach one can generate an arbitrary output optical field within the accessible field of view and range of spatial frequencies given by fibre core diameter and numerical aperture, respectively, that contains over 80% of the total available power. We also show that this technology has applications in biophotonics. As an example, we demonstrate the manipulation of colloidal microparticles. © 2011 Optical Society of America
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                Author and article information

                Journal
                Nat Commun
                Nat Commun
                Nature Communications
                Nature Pub. Group
                2041-1723
                28 August 2012
                : 3
                : 1027
                Affiliations
                [1 ] simpleSchool of Medicine, University of St. Andrews , North Haugh, St. Andrews KY16 9TF, UK.
                [2 ] simpleSUPA, School of Physics and Astronomy, University of St. Andrews , North Haugh, St. Andrews KY16 9SS, UK.
                Author notes
                Article
                ncomms2024
                10.1038/ncomms2024
                3432471
                22929784
                efa197b9-f4b1-4608-b6ec-912778b38532
                Copyright © 2012, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

                This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

                History
                : 08 May 2012
                : 27 July 2012
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