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Electrophysiological characteristics of cholinergic and non-cholinergic neurons in the rat medial septum-diagonal band complex
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Abstract
We examined the electrophysiological properties of cholinergic and non-cholinergic
neurons in the medial septum-diagonal band complex (MSDB) of the rat in the in vitro
slice preparation. Cells were identified electrophysiologically, filled with Lucifer
yellow, fixed and processed for immunohistochemistry with fluorescent labeled anti-choline
acetyltransferase (ChAT) antibody. Cholinergic and non-cholinergic neurons differed
in action potential parameters, spike afterpotentials and in current-voltage relationships.
In addition, cholinergic neurons expressed a potent transient outward rectification
in response to a depolarizing current pulse.