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      Influence of Murine Renal Sexual Dimorphism on Amiloride-Induced Hyperkalemia

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          The present study investigated the influence of androgens in potassium homeostasis both under normal conditions and when potassium balance was affected by the mild diuretic amiloride. Our results indicate the existence of a clear sexual dimorphism in renal and plasma potassium content in CD1 mice, adult males having a higher plasma potassium concentration than females or 40-day-old male mice (4.6 ± 1.0 vs. 3.9 ± 0.9 mEq/l). Plasma K<sup>+</sup> concentration was increased by testosterone treatment and decreased after orchiectomy, while the opposite occurred in the case of renal potassium concentration. Amiloride was well tolerated by CD1 female mice, but induced severe hyperkalemia in male mice, where it was also associated with a high rate of mortality. Testosterone treatment increased the toxicity of the diuretic in both CD1 female and male mice. Histopathological analysis of kidneys from CD1 male mice treated with amiloride revealed alterations at the proximal and distal tubule level. These results strongly suggest that androgens may produce adverse effects in renal function.

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          Androgens in men--uses and abuses.

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            Effects of aging on the renal glomerulus.

            The biologic price of aging includes progressive deterioration of renal function and structure. After the age of 30, glomerular filtration and renal blood flow rates decline in a linear fashion, so that values in octagenarians are only half to two thirds those measured in young adults. Renal mass similarly declines, and the incidence of sclerotic glomeruli increases with advancing age. Accordingly, the aging kidney is at high risk of eventual failure when functioning nephron number is further reduced by acquired renal disease. Recent evidence suggests that limitation of dietary protein intake delays the development of age- and disease-related glomerular sclerosis in experimental animals, and that dietary protein restriction may postpone end-stage renal disease in patients with progressive renal insufficiency.
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              Cardiovascular toxicity of anabolic steroids.

               R Rockhold (1993)

                Author and article information

                Nephron Physiol
                Nephron Physiology
                S. Karger AG
                November 2003
                01 December 2003
                : 95
                : 3
                : p57-p66
                Departments of aPharmacology, bPathology and cBiochemistry and Molecular Biology, Faculty of Medicine, University of Murcia, Campus de Espinardo, Murcia, Spain
                74331 Nephron Physiol 2003;95:p57–p66
                © 2003 S. Karger AG, Basel

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                Page count
                Figures: 6, Tables: 3, References: 44, Pages: 1
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/74331
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