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      Sorting out the cellular functions of sorting nexins.

      Nature reviews. Molecular cell biology

      physiology, Yeasts, Vesicular Transport Proteins, Protein Transport, Protein Structure, Tertiary, Protein Binding, Phylogeny, metabolism, Phospholipids, Molecular Sequence Data, Models, Molecular, Models, Biological, Humans, Cytoplasmic Vesicles, Cell Membrane, genetics, classification, Carrier Proteins, Biological Transport, Amino Acid Sequence, Amino Acid Motifs

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          Abstract

          Sorting nexins are a diverse group of cellular trafficking proteins that are unified by the presence of a phospholipid-binding motif - the PX domain. The ability of these proteins to bind specific phospholipids, as well as their propensity to form protein-protein complexes, points to a role for these proteins in membrane trafficking and protein sorting. It will be interesting to determine whether the various sorting nexins have specialized or generalized roles in protein trafficking.

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          Journal
          10.1038/nrm974
          12461558

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