Coatings as the useful drug delivery system for the prevention of implant-related infections

Abstract

Implant-related infections (IRIs) which led to a large amount of medical expenditure were caused by bacteria and fungi that involve the implants in the operation or in ward. Traditional treatments of IRIs were comprised of repeated radical debridement, replacement of internal fixators, and intravenous antibiotics. It needed a long time and numbers of surgeries to cure, which meant a catastrophe to patients. So how to prevent it was more important than to cure it. As an excellent local release system, coating is a good idea by its local drug infusion and barrier effect on resisting biofilms which were the main cause of IRIs. So in this review, materials used for coatings and evidences of prevention were elaborated.

Contributors

Chenhao Pan: [e-mail]

Zubin Zhou: [e-mail]

Xiaowei Yu:

ORCID: http://orcid.org/0000-0002-8235-4907

[phone] , [e-mail]

Journal

Journal ID (nlm-ta): J Orthop Surg Res

Journal ID (iso-abbrev): J Orthop Surg Res

Title: Journal of Orthopaedic Surgery and Research

Publisher: BioMed Central (London )

ISSN (Electronic): 1749-799X

Publication date (Electronic): 3 September 2018

Publication date PMC-release: 3 September 2018

Publication date Collection: 2018

Volume: 13

Affiliations

[1 ]ISNI 0000 0004 1798 5117, GRID grid.412528.8, Department of Orthopaedic Surgery, , Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, ; Shanghai, 200233 China

[2 ]ISNI 0000 0001 2323 5732, GRID grid.39436.3b, Department of Orthopaedic Surgery, Shanghai Sixth People’s Hospital East Campus, , Shanghai University of Medicine and Health Sciences, ; Shanghai, 201306 China

Article

Publisher ID: 930

DOI: 10.1186/s13018-018-0930-y

PMC ID: 6122451

PubMed ID: 30176886

Copyright statement: © The Author(s). 2018

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;

Award ID: 81572155

Award Recipient : Xiaowei Yu

Categories

Subject: Review

Custom metadata

issue-copyright-statement © The Author(s) 2018