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      Coatings as the useful drug delivery system for the prevention of implant-related infections

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          Abstract

          Implant-related infections (IRIs) which led to a large amount of medical expenditure were caused by bacteria and fungi that involve the implants in the operation or in ward. Traditional treatments of IRIs were comprised of repeated radical debridement, replacement of internal fixators, and intravenous antibiotics. It needed a long time and numbers of surgeries to cure, which meant a catastrophe to patients. So how to prevent it was more important than to cure it. As an excellent local release system, coating is a good idea by its local drug infusion and barrier effect on resisting biofilms which were the main cause of IRIs. So in this review, materials used for coatings and evidences of prevention were elaborated.

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          Most cited references 112

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          Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee.

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            Silver as antibacterial agent: ion, nanoparticle, and metal.

            The antibacterial action of silver is utilized in numerous consumer products and medical devices. Metallic silver, silver salts, and also silver nanoparticles are used for this purpose. The state of research on the effect of silver on bacteria, cells, and higher organisms is summarized. It can be concluded that the therapeutic window for silver is narrower than often assumed. However, the risks for humans and the environment are probably limited. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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              Drug Discovery: A Historical Perspective

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                Author and article information

                Contributors
                pchh@sjtu.edu.cn
                zhouzubin@sjtu.edu.cn
                +86-21-3829-7774 , yuxw@sjtu.edu.cn
                Journal
                J Orthop Surg Res
                J Orthop Surg Res
                Journal of Orthopaedic Surgery and Research
                BioMed Central (London )
                1749-799X
                3 September 2018
                3 September 2018
                2018
                : 13
                Affiliations
                [1 ]ISNI 0000 0004 1798 5117, GRID grid.412528.8, Department of Orthopaedic Surgery, , Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, ; Shanghai, 200233 China
                [2 ]ISNI 0000 0001 2323 5732, GRID grid.39436.3b, Department of Orthopaedic Surgery, Shanghai Sixth People’s Hospital East Campus, , Shanghai University of Medicine and Health Sciences, ; Shanghai, 201306 China
                Article
                930
                10.1186/s13018-018-0930-y
                6122451
                30176886
                © The Author(s). 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;
                Award ID: 81572155
                Award Recipient :
                Categories
                Review
                Custom metadata
                © The Author(s) 2018

                Surgery

                biofilm, implant-related infections, coating, osteomyelitis, local drug delivery system

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