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      The essential role of osteoclast-derived exosomes in magnetic nanoparticle-infiltrated hydroxyapatite scaffold modulated osteoblast proliferation in an osteoporosis model.

      1 , , , , ,

      Nanoscale

      Royal Society of Chemistry (RSC)

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          Abstract

          Magnetic hydroxyapatite (MHA) scaffolds promoted osteoblast proliferation in a model of osteoporosis through altering the osteoclast-derived exosomal cargo and decreasing the efficiency of exosome uptake by osteoblasts. Noticeably, certain proteins including ubiquitin, ATP and reactive oxygen species decreased in the osteoclast-derived exosomal cargo with MHA stimulation, while Rho kinase increased.

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          Author and article information

          Journal
          Nanoscale
          Nanoscale
          Royal Society of Chemistry (RSC)
          2040-3372
          2040-3364
          Apr 30 2020
          : 12
          : 16
          Affiliations
          [1 ] National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610064, P.R. China. jinghe30@scu.edu.cn wuyao@scu.edu.cn.
          Article
          10.1039/d0nr00867b
          32285072

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