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The essential role of osteoclast-derived exosomes in magnetic nanoparticle-infiltrated hydroxyapatite scaffold modulated osteoblast proliferation in an osteoporosis model.
Apr 30 2020
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Abstract
Magnetic hydroxyapatite (MHA) scaffolds promoted osteoblast proliferation in a model of osteoporosis through altering the osteoclast-derived exosomal cargo and decreasing the efficiency of exosome uptake by osteoblasts. Noticeably, certain proteins including ubiquitin, ATP and reactive oxygen species decreased in the osteoclast-derived exosomal cargo with MHA stimulation, while Rho kinase increased.