The microstructural changes of a Hastelloy alloy under 10 MeV electron irradiation at 650 °C for 700 h to a total fluence of 2 × 10 – 3 dpa (displacements per atom) were investigated by transmission electron microscopy and by 3-dimensional atom-probe tomography utilizing a local-electrode atom-probe tomograph. Transmission electron microscopy analysis before irradiation reveals two types of precipitates: (i) spheroidal with a mean diameter of 22 nm; and (ii) ones with an irregular morphology of a few nm in diameter. The spheroidal precipitates (i) are coherent with the fcc matrix and their number density is ∼3 × 10 21 m – 3. Electron diffraction patterns from these precipitates exhibit superlattice reflections corresponding to the L1 2 ordered structure. The chemical composition as measured by atom-probe tomography, is about 75 at.% Ni with additions of Al, Ti and Mo. The other type of precipitate (ii) is mainly enriched in Ni and Mo and its number density is ca. 3.6 × 10 22 m – 3. The diffuse diffraction intensity maxima arising from these precipitates are observed at <1 1/2 0> fcc, which are attributed to compositional short-range order. After electron irradiation, the Ni – Al-rich precipitates (i) exhibiting L1 2 superlattice reflections have disappeared completely, while the diffuse intensity maxima from the Ni – Mo rich clusters (ii) are still visible. The results are discussed with respect to the influence of the electron irradiation on the morphology and structural changes of the ordered precipitates.