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      Taxus chinensis ameliorates diabetic nephropathy through down-regulating TGF- β1/Smad pathway

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          Abstract

          Diabetic nephropathy (DN) is one of the common microvascular complications of diabetes mellitus. Renal fibrosis is closely related to the deterioration of renal function. The present study aimed to investigate protective effect of Taxus chinensis on high-fat diet/streptozotocin-induced DN in rats and explore the underlying mechanism of action. The rat DN model was established via feeding high fat diet for 4 weeks and subsequently injecting streptozotocin (30 mg·kg −1 body weight) intraperitoneally. The rats with blood glucose levels higher than 16.8 mmol·L −1 were selected for experiments. The DN rats were treated with Taxus chinensis orally (0.32, 0.64, and 1.28 g·kg −1) once a day for 8 weeks. Taxus chinensis significantly improved the renal damage, which was indicated by the decreases in 24-h urinary albumin excretion rate, blood serum creatinine, and blood urea nitrogen. Histopathological examination confirmed the protective effect of Taxus chinensis. The thickness of glomerular basement membrane was reduced, and proliferation of mesangial cells and podocytes cells and increase in mesangial matrix were attenuated. Further experiments showed that Taxus chinensis treatment down-regulated the expression of TGF- β1 and α-SMA, inhibited phosphorylation of Smad2 and Smad3. These results demonstrated that Taxus chinensis alleviated renal injuries in DN rats, which may be associated with suppressing TGF- β1/Smad signaling pathway.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 February 2018
          : 16
          : 2
          : 90-96
          Affiliations
          1Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China
          2Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
          3Liqun Hospital, Shanghai 200333, China
          Author notes
          *Corresponding author: ZHANG Xue-Mei, E-mails: xuemzhang@ 123456fudan.edu.cn ; PENG Wen, pengwen_01@ 123456vip.sina.com

          ΔThese two authors contributed equally to this work.

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30034-7
          10.1016/S1875-5364(18)30034-7
          29455733
          Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Shanghai Health Bureau Project
          Award ID: 20124007
          Award ID: 20134120
          This work was supported by Shanghai Health Bureau Project (Nos. 20124007 and 20134120).

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