Chiara Parravicini: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
VisualizationRole: Writing – original draft
Davide Lecca: Role: ConceptualizationRole: InvestigationRole: SupervisionRole: Writing – review
& editing
Davide Marangon: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
VisualizationRole: Writing – original draft
Giusy Tindara Coppolino: Role: InvestigationRole: Methodology
Simona Daniele: Role: Data curationRole: MethodologyRole: Visualization
Elisabetta Bonfanti: Role: Data curationRole: InvestigationRole: MethodologyRole: Writing – original draft
Marta Fumagalli: Role: SupervisionRole: Writing – review & editing
Luca Raveglia: Role: ConceptualizationRole: Methodology
Claudia Martini: Role: InvestigationRole: Supervision
Elisabetta Gianazza: Role: Supervision
Maria Letizia Trincavelli: Role: Conceptualization
Maria P. Abbracchio:
ORCID: http://orcid.org/0000-0002-7833-3388
Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
ResourcesRole: SupervisionRole: Writing – review & editing
Ivano Eberini: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: ResourcesRole:
SupervisionRole: Writing – review & editing
Fernando de Castro: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
22
April
2020
Publication date Collection: 2020
Volume: 15
Issue: 4
Electronic Location Identifier: e0231483
Affiliations
[1
]
Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di
Milano, Milan, Italy
[2
]
Department of Pharmacy, University of Pisa, Pisa, Italy
[3
]
Aptuit Srl, Verona, Italy
[4
]
Dipartimento di Scienze Farmacologiche e Biomolecolari & DSRC, Università degli Studi
di Milano, Milan, Italy
Instituto Cajal-CSIC, SPAIN
Author notes
Competing Interests: All the compounds included in this Manuscript are protected by an international Patent
Cooperation Treaty (PCT/EP2012/058500, Gpr17 receptor modulators) deposited on May
09th, 2012 and granted on August 6th, 2014. Inventors: Maria Pia Abbracchio, Mario
Alberto Battaglia, Ivano Eberini, Marta Fumagalli, Chiara Parravicini, Cristina Sensi,
Paola Zaratin This PCT has generated the following patents and national applications:
Italy: granted patent - 102012902048704 (MI2012A000785), released on 2014/10/23; Italy:
granted patent - 102012902048705 (MI2012A000786), released on 2014/10/23; Japan: granted
patent - 2015-510655, released on 2017/01/27; USA: granted patent - 9879030, released
on 2018/01/30; China: granted patent - 104428288B, released on 2018/03/13; Israel:
granted patent - 235557, released on 2018/11/29; Europe: granted patent - 2850068
(B1) released on 2019/05/29; Korea: 10-2014-7034470, application discontinuation.
This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Non-financial competing interests: Prof. Ivano Eberini is a member of the Editorial
Board of PLOS ONE. I declare that one of the authors of this manuscript has a commercial
affiliation: “Luca Raveglia, Aptuit Srl (Evotech Company), Via Alessandro Fleming
4, 37135 Verona, Italy”. This does not alter our adherence to PLOS ONE policies on
sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-19-35030
DOI: 10.1371/journal.pone.0231483
PMC ID: 7176092
PubMed ID: 32320409
SO-VID: efe7cf9f-c6a0-427d-82ba-7ee96ac72985
Copyright © © 2020 Parravicini et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100007366, Fondazione Italiana Sclerosi Multipla;
Award ID: 2013/S/2
Award Recipient
:
ORCID: http://orcid.org/0000-0002-7833-3388
Maria P. Abbracchio
Funded by: Ministero dell’Istruzione, dell’Università e della Ricerca (IT)
Award ID: FFABR 2017
Award Recipient
:
Ivano Eberini
Funded by: funder-id http://dx.doi.org/10.13039/100007366, Fondazione Italiana Sclerosi Multipla;
Award ID: 2013/S/2
Award Recipient
:
Ivano Eberini
Funded by: funder-id http://dx.doi.org/10.13039/100012352, Università degli Studi di Milano;
Award ID: Linea 2 – Azione A 2017
Award Recipient
:
Marta Fumagalli
Funded by: funder-id http://dx.doi.org/10.13039/100012352, Università degli Studi di Milano;
Award ID: Linea 2 – Azione A 2017
Award Recipient
:
Ivano Eberini
This study was supported by Fondazione Italiana Sclerosi Multipla (FISM,
https://www.aism.it/) to IE and to MPA (2013/S/2) and by “Department of Excellence” grant program from
Italian Ministry of University and Research (MIUR) 2018-2022. FISM provided support
in the form of salaries for authors [CP, DL, DM]. Funders did not have any additional
role in the study design, data collection and analysis, decision to publish, or preparation
of the manuscript. IE acknowledges funding support from MIUR (FFABR2017). IE and MF
gratefully acknowledges departmental “Linea 2 – Azione A 2017” funding (
http://www.disfeb.unimi.it/ecm/home). Aptuit srl has been recruited to perform in vivo DMPK experiments as professional
service under a commercial agreement and did not provide any financial support to
the research. This does not alter our adherence to PLOS ONE policies on sharing data
and materials.
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