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      Angiogenesis: an organizing principle for drug discovery?

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      Nature reviews. Drug discovery
      Springer Science and Business Media LLC

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          Abstract

          Angiogenesis--the process of new blood-vessel growth--has an essential role in development, reproduction and repair. However, pathological angiogenesis occurs not only in tumour formation, but also in a range of non-neoplastic diseases that could be classed together as 'angiogenesis-dependent diseases'. By viewing the process of angiogenesis as an 'organizing principle' in biology, intriguing insights into the molecular mechanisms of seemingly unrelated phenomena might be gained. This has important consequences for the clinical use of angiogenesis inhibitors and for drug discovery, not only for optimizing the treatment of cancer, but possibly also for developing therapeutic approaches for various diseases that are otherwise unrelated to each other.

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          Author and article information

          Journal
          Nat Rev Drug Discov
          Nature reviews. Drug discovery
          Springer Science and Business Media LLC
          1474-1776
          1474-1776
          Apr 2007
          : 6
          : 4
          Affiliations
          [1 ] Childrens Hospital and Harvard Medical School Boston, Massachusetts, USA. judah.folkman@childrens.harvard.edu
          Article
          nrd2115
          10.1038/nrd2115
          17396134
          eff01c28-d6a7-43e4-a492-42efdf51ba40
          History

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