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      A Mini Review on Discovery and Synthesis of Remdesivir as an Effective and Promising Drug against COVID-19

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          Abstract

          The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as a new human coronavirus has begun spreading over Wuhan City/China in December 2019, and then spread rapidly worldwide, causing pneumonia called COVID-19. Up to now, the scientists have extensively attempted to find effective vaccines and drugs for treatment of coronavirus infections. To this end, various pharmaceutical agents are undergoing the clinical studies to assess their potency and efficacy against COVID-19. Based on the new findings, the U.S. food and drug administration (FDA) has issued an emergency use authorization for remdesivir as an effective anti-viral for remedying the hospitalized COVID-19 patients. Recently, the European medicines agency has authorized the use of remdesivir for the treatment of COVID-19. Remdesivir as a nucleotide prodrug exhibits broad-spectrum antiviral activities against RNA viruses. In this short review, we have rendered a brief overview of discovery and synthesis for remdesivir.

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          • Record: found
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          Practical synthesis of 1′-substituted Tubercidin C-nucleoside analogs

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            • Record: found
            • Abstract: not found
            • Book: not found

            Covid 19—The New Age Pandemic

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              ChemMedChem

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                Author and article information

                Contributors
                El.zarenezhad@gmail.com , El.Zarenezhad@fums.ac.ir
                Journal
                Russ J Bioorg Chem
                Russ J Bioorg Chem
                Russian Journal of Bioorganic Chemistry
                Pleiades Publishing (Moscow )
                1068-1620
                1608-330X
                11 June 2021
                2021
                : 47
                : 3
                : 609-621
                Affiliations
                [1 ]GRID grid.411135.3, ISNI 0000 0004 0415 3047, Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, ; Fasa, Iran
                [2 ]GRID grid.444860.a, ISNI 0000 0004 0600 0546, Medicinal Chemistry Research Laboratory, Department of Chemistry Shiraz University of Technology, ; 71555-313 Shiraz, Iran
                [3 ]GRID grid.411135.3, ISNI 0000 0004 0415 3047, Department of Medical Pharmacology, School of Medicine, Fasa University of Medical Sciences, ; Fasa, Iran
                Article
                8324
                10.1134/S1068162021030183
                8193954
                © Pleiades Publishing, Ltd. 2021, ISSN 1068-1620, Russian Journal of Bioorganic Chemistry, 2021, Vol. 47, No. 3, pp. 609–621. © Pleiades Publishing, Ltd., 2021.

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                Categories
                Mini Review
                Custom metadata
                © Pleiades Publishing, Ltd. 2021

                remdesivir, coronavirus, covid-19, synthesis, sars-cov-2

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