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      Novel evidence of ghrelin and growth hormone segretagogue receptor expression by human ocular tissues.

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          Abstract

          The gastrointestinal peptide hormone ghrelin (Ghr) was discovered in 1999 as the endogenous ligand for the growth hormone secretagogue receptor (GHSR-1a). It is a pleiotropic peptide that modulates a wide spectrum of biological activities, such as growth hormone (GH) release, feeding stimulation, adiposity and cardiovascular actions. The presence of Ghr mRNA in the iris and ciliary body (CB) epithelium was recently demonstrated in animal models, where a possible myorelaxing effect on the iris muscles has been suggested. Based on these observations, the aim of our study was to investigate the Ghr and GHSR-1a expression and localization in the normal human eye.

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          Author and article information

          Journal
          Regul. Pept.
          Regulatory peptides
          Elsevier BV
          1873-1686
          0167-0115
          May 2014
          : 190-191
          Affiliations
          [1 ] Department of Medicine and Aging Sciences, "G. d'Annunzio" University of Chieti-Pescara, 66013 Chieti, Italy.
          [2 ] Department of Experimental and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara, 66013 Chieti, Italy.
          [3 ] Department of Biomedical and Surgical Sciences University of Ferrara, 44123 Ferrara, Italy.
          [4 ] Department of Medicine and Aging Sciences, "G. d'Annunzio" University of Chieti-Pescara, 66013 Chieti, Italy. Electronic address: a.dibaldassarre@unich.it.
          Article
          S0167-0115(14)00043-3
          10.1016/j.regpep.2014.04.005
          24809812

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