Alessia Di Fonso 1 , Barbara Ghinassi 1 , Pascal Izzicupo 1 , Roberta Zappacosta 2 , Marcella Liberatore 2 , Carla Enrica Gallenga 3 , Maria Angela D'Amico 1 , Pier Enrico Gallenga 2 , Angela Di Baldassarre 4
The gastrointestinal peptide hormone ghrelin (Ghr) was discovered in 1999 as the endogenous ligand for the growth hormone secretagogue receptor (GHSR-1a). It is a pleiotropic peptide that modulates a wide spectrum of biological activities, such as growth hormone (GH) release, feeding stimulation, adiposity and cardiovascular actions. The presence of Ghr mRNA in the iris and ciliary body (CB) epithelium was recently demonstrated in animal models, where a possible myorelaxing effect on the iris muscles has been suggested. Based on these observations, the aim of our study was to investigate the Ghr and GHSR-1a expression and localization in the normal human eye.