Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Ovarian aging is characterized by a progressive decline in ovarian function. With the increase in life expectancy worldwide, ovarian aging has gradually become a key health problem among women. Over the years, various strategies have been developed to preserve fertility in women, while there are currently no clinical treatments to delay ovarian aging. Recently, advances in biomaterials and technologies, such as three-dimensional (3D) printing and microfluidics for the encapsulation of follicles and nanoparticles as delivery systems for drugs, have shown potential to be translational strategies for ovarian aging. This review introduces the research progress on the mechanisms underlying ovarian aging, and summarizes the current state of biomaterials in the evaluation and treatment of ovarian aging, including safety, potential applications, future directions and difficulties in translation.

Graphical Abstract

Related collections

Most cited references 319

Record: found
Abstract: found
Article: not found

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel, Gisela D'Angelo, Graça Raposo (2018)

Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising exosomes and microvesicles, which originate from the endosomal system or which are shed from the plasma membrane, respectively. They are present in biological fluids and are involved in multiple physiological and pathological processes. Extracellular vesicles are now considered as an additional mechanism for intercellular communication, allowing cells to exchange proteins, lipids and genetic material. Knowledge of the cellular processes that govern extracellular vesicle biology is essential to shed light on the physiological and pathological functions of these vesicles as well as on clinical applications involving their use and/or analysis. However, in this expanding field, much remains unknown regarding the origin, biogenesis, secretion, targeting and fate of these vesicles.

0 comments Cited 2326 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Is Open Access

Extracellular vesicles: Exosomes, microvesicles, and friends

Graça Raposo, Willem Stoorvogel (2013)

Cells release into the extracellular environment diverse types of membrane vesicles of endosomal and plasma membrane origin called exosomes and microvesicles, respectively. These extracellular vesicles (EVs) represent an important mode of intercellular communication by serving as vehicles for transfer between cells of membrane and cytosolic proteins, lipids, and RNA. Deficiencies in our knowledge of the molecular mechanisms for EV formation and lack of methods to interfere with the packaging of cargo or with vesicle release, however, still hamper identification of their physiological relevance in vivo. In this review, we focus on the characterization of EVs and on currently proposed mechanisms for their formation, targeting, and function.

0 comments Cited 1728 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Alginate: properties and biomedical applications.

Kuen Lee, David Mooney (2012)

Alginate is a biomaterial that has found numerous applications in biomedical science and engineering due to its favorable properties, including biocompatibility and ease of gelation. Alginate hydrogels have been particularly attractive in wound healing, drug delivery, and tissue engineering applications to date, as these gels retain structural similarity to the extracellular matrices in tissues and can be manipulated to play several critical roles. This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.

0 comments Cited 1191 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Wenwen Wang: petrawang@163.com

Shixuan Wang: sxwang@tjh.tjmu.edu.cn

Journal

Journal ID (nlm-ta): J Nanobiotechnology

Journal ID (iso-abbrev): J Nanobiotechnology

Title: Journal of Nanobiotechnology

Publisher: BioMed Central (London )

ISSN (Electronic): 1477-3155

Publication date (Electronic): 11 August 2022

Publication date PMC-release: 11 August 2022

Publication date Collection: 2022

Volume: 20

Electronic Location Identifier: 374

Affiliations

[1 ]GRID grid.412793.a, ISNI 0000 0004 1799 5032, Department of Obstetrics and Gynecology, , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, ; Wuhan, 430030 Hubei China

[2 ]National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, 430030 Hubei China

[3 ]GRID grid.419897.a, ISNI 0000 0004 0369 313X, Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, ; Wuhan, 430030 Hubei China

[4 ]GRID grid.413247.7, ISNI 0000 0004 1808 0969, Department of Obstetrics and Gynecology, , Zhongnan Hospital of Wuhan University, ; Wuhan, 430071 Hubei China

Article

Publisher ID: 1566

DOI: 10.1186/s12951-022-01566-8

PMC ID: 9367160

PubMed ID: 35953871

SO-VID: f0010a0d-960c-4bf7-84b8-be7f68d43a59

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 23 April 2022

Date accepted : 17 July 2022

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;

Award ID: 81873824

Award ID: 82001514

Award ID: 82001498

Award ID: 8210062421

Award ID: 22104040

Award ID: 81701420

Award ID: 81902669

Funded by: FundRef http://dx.doi.org/10.13039/501100012226, Fundamental Research Funds for the Central Universities;

Award ID: HSUT: 2021yjsCXCY087

Award Recipient : Shixuan Wang

Custom metadata

ScienceOpen disciplines: Biotechnology

Keywords: ovarian aging,biomaterials,evaluation,treatment

Data availability:

ScienceOpen disciplines: Biotechnology

Keywords: ovarian aging, biomaterials, evaluation, treatment

Comments

Comment on this article

scite_

Cited by 5

See all cited by

Most referenced authors 5,756

See all reference authors

Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging

Read this article at

Abstract

Graphical Abstract

Related collections

iGEM

Most cited references 319

Shedding light on the cell biology of extracellular vesicles

Extracellular vesicles: Exosomes, microvesicles, and friends

Alginate: properties and biomedical applications.

Author and article information

Contributors

Journal

Affiliations

Article

History

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 587

Cited by 5

Most referenced authors 5,756