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      Direct Calculation of KT/V

      Nephron

      S. Karger AG

      Hemodialysis, Adequacy of dialysis, Dialysateurea, Dialyzer clearance, Urea volume of distribution, Urea kinetic modeling

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          Abstract

          KT/V, the normalized whole-body urea clearance, is becoming accepted as a standard measurement for monitoring the adequacy of hemodialysis. Current methods for its calculation are limited by inaccurate knowledge of dialyzer urea clearance (K) and urea volume of distribution (V). We report a simple formula for calculation of KT/V from pre-, post- and middialysis blood urea nitrogen. Evaluation of 37 hemodialysis treatments by measurement of total dialysate urea revealed that (1) urea kinetic modeling consistently overestimated V; (2) conventional arteriovenous sampling overstimated K by a mean of 23%, and (3) KT/V derived from the simple formula was compared to values generated by four other methods and found to more precisely estimate true KT/V.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1988
          1988
          09 December 2008
          : 50
          : 3
          : 191-195
          Affiliations
          Nephrology Section, Veterans Administration Medical Center, and State University of New York Health Science Center, Brooklyn, N.Y., USA
          Article
          185156 Nephron 1988;50:191–195
          10.1159/000185156
          3226454
          © 1988 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

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