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      Correlación de los días de estancia hospitalaria con el índice neutrófilo-linfocítico en pacientes con diagnóstico de angina de Ludwig Translated title: Correlation of the days of hospital stay with the neutrophil-lymphocyte ratio in patients with a diagnosis of Ludwig's angina: pilot study

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          Abstract

          RESUMEN Introducción: El objetivo del presente estudio es correlacionar los días de estancia hospitalaria con el índice neutrófilo-linfocitico (INL) como biomarcador, en los pacientes con diagnóstico de angina de Ludwig que fueron admitidos en urgencias. Pacientes y métodos: Se realizó una búsqueda en los expedientes clínicos del hospital, donde solo se obtuvieron los que tenían diagnóstico de angina de Ludwig desde junio de 2016 hasta junio de 2020, y que cumplieran con los criterios de selección. Posteriormente se recabaron los datos sociodemográficos, días de hospitalización, biometría hemática y valores de neutrófilos y linfocitos para su posterior análisis estadístico. Resultados: Obtuvimos 21 pacientes (9 mujeres y 12 hombres). La edad promedio fue de 43,1 años (rango: 27-70 años). Se transformó la variable de días de hospitalización: en corta estancia hospitalaria aquellos pacientes que estuvieron hospitalizados 5 días o menos; y los de larga estancia hospitalaria aquellos pacientes que estuvieron hospitalizados 6 días o más, para el INL se consideró un índice alto aquellos pacientes que se encontraran con un INL ≥ 6 y un índice bajo aquellos pacientes con un índice ≤ 5, tomando en cuenta el punto de corte con respecto a estudios previamente realizados. Se observó que aquellos pacientes con un INL alto tuvieron una estancia hospitalaria larga, y de acuerdo con los resultados obtuvimos significación estadística (p = 0,02). Conclusiones: El INL parece ser un buen biomarcador para predecir los días de estancia hospitalaria de los pacientes con angina de Ludwig. Sin embargo, se necesitan más estudios para confirmar nuestros resultados.

          Translated abstract

          ABSTRACT Introduction: The aim of this study is to correlate the number of days of hospital stay with the neutrophil-lymphocyte index (NLI) as a biomarker in patients diagnosed with Ludwig's angina who were admitted to the emergency department. Patients and methods: A search was conducted in the hospital's medical records, where only those with a diagnosis of Ludwig's angina from June 2016 to June 2020 and that met the selection criteria were obtained. Afterwards, sociodemographic data, days of hospitalization, hematological parameters, and values of neutrophils and lymphocytes were collected for subsequent statistical analysis. Results: We obtained 21 patients (9 females and 12 males). The average age was 43.1 years (range: 27-70 years). The variable of days of hospitalization was transformed into: short hospital stay for patients who were hospitalized for 5 days or less, and long hospital stay for patients who were hospitalized for 6 days or more. For the NLI, a high index was considered for patients with an NLI ≥ 6 and a low index for patients with an NLI ≤ 5, taking into account the cut-off point with respect to previously conducted studies. We observed that patients with a high NLI had a long hospital stay and according to the results, we obtained statistical significance (p = 0.02). Conclusions: The NLI appears to be a good biomarker for predicting the number of days of hospital stay for patients with Ludwig's angina. However, more studies are needed to confirm our results.

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          Inflammation and cancer: back to Virchow?

          The response of the body to a cancer is not a unique mechanism but has many parallels with inflammation and wound healing. This article reviews the links between cancer and inflammation and discusses the implications of these links for cancer prevention and treatment. We suggest that the inflammatory cells and cytokines found in tumours are more likely to contribute to tumour growth, progression, and immunosuppression than they are to mount an effective host antitumour response. Moreover cancer susceptibility and severity may be associated with functional polymorphisms of inflammatory cytokine genes, and deletion or inhibition of inflammatory cytokines inhibits development of experimental cancer. If genetic damage is the "match that lights the fire" of cancer, some types of inflammation may provide the "fuel that feeds the flames". Over the past ten years information about the cytokine and chemokine network has led to development of a range of cytokine/chemokine antagonists targeted at inflammatory and allergic diseases. The first of these to enter the clinic, tumour necrosis factor antagonists, have shown encouraging efficacy. In this article we have provided a rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases.
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            Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer.

            Simple methods to identify colorectal cancer patients at risk of recurrence are needed. This study aimed to determine if neutrophil-to-lymphocyte ratio (NLR) predicts survival in colorectal cancer patients. Two-hundred thirty patients diagnosed with colorectal cancer over a two-year period were identified from a prospectively maintained colorectal cancer database. NLR was calculated from pre-operative full blood counts. In the case of patients who did not undergo surgery, the full blood count from their out-patient visit was used. Known prognostic factors were recorded. Overall and cancer-specific survival were calculated. Pre-operative NLR greater than 5 correlated with overall and cancer-specific survival in univariate analyses. NLR was not independent of Dukes stage. Pre-operative NLR may represent a simple method of identifying colorectal cancer patients with a poor prognosis pre-operatively. Copyright 2005 Wiley-Liss, Inc.
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              Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

              Objective This systematic review aimed to measure the association between neutrophil lymphocyte ratio (NLR) and cardiovascular disease (CVD) risk. Methods Relevant studies were identified from Medline and Scopus databases. Observational studies with NLR as a study factor were eligible for review. The outcomes of interest were any type of CVD including acute coronary syndrome, coronary artery disease, stroke, or a composite of these cardiovascular events. Mean differences in NLR between CVD and non-CVD patients were pooled using unstandardized mean difference (USMD). Odds ratios of CVD between high and low NLR groups were pooled using a random effects model. Results Thirty-eight studies (n=76,002) were included. High NLR was significantly associated with the risks of CAD, ACS, stroke, and composite cardiovascular events with pooled ORs of 1.62 (95% CI: 1.38-1.91), 1.64 (95% CI: 1.30, 2.05), 2.36 (95% CI: 1.44, 2.89), and 3.86 (95% CI: 1.73, 8.64), respectively. In addition, mean NLRs in CAD, ACS, and stroke patients were significantly higher than in control groups. Conclusion High NLR was associated with CAD, ACS, stroke, and composite cardiovascular events. Therefore, NLR may be a useful CVD biomarker.
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                Author and article information

                Journal
                maxi
                Revista Española de Cirugía Oral y Maxilofacial
                Rev Esp Cirug Oral y Maxilofac
                Sociedad Española de Cirugía Oral y Maxilofacial y de Cabeza y Cuello (Madrid, Madrid, Spain )
                1130-0558
                2173-9161
                December 2022
                : 44
                : 4
                : 135-140
                Affiliations
                [3] orgnameInstituto de Seguridad y Servicios Sociales de los Trabajadores del Estado orgdiv1Servicio de Geriatría México
                [2] San Luis orgnameUniversidad Autónoma de San Luís Potosí orgdiv1Servicio de Cirugía Oral y Maxilofacial orgdiv2Facultad de Estomatología Mexico
                [1] San Luis orgnameHospital Central Dr. Ignacio Morones Prieto orgdiv1Servicio de Cirugía Oral y Maxilofacial México
                [4] San Luis orgnameUniversidad Autónoma de San Luís Potosí orgdiv1Facultad de Estomatología orgdiv2Laboratorio de Investigación Clínica Mexico
                Article
                S1130-05582022000400002 S1130-0558(22)04400400002
                10.20986/recom.2023.1402/2022
                f0183196-4fe4-48ba-833d-8f6f3df637a6

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

                History
                : 14 October 2022
                : 09 February 2023
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 20, Pages: 6
                Product

                SciELO Spain

                Categories
                Originales

                Ludwig's angina,biomarker,correlation,hospital stay,red cell count,neutrophil-lymphocyte index,Angina de Ludwig,biomarcador,correlación,estancia hospitalaria,conteo de células rojas,índice neutrófilo-linfocitario

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