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Biosynthesis of Terpenes. Preparation of (E)-1-Hydroxy-2-methyl-but-2-enyl 4-Diphosphate, an Intermediate of the Deoxyxylulose Phosphate Pathway†
Sabine Amslinger ,
Klaus Kis ,
Stefan Hecht ,
Petra Adam ,
Felix Rohdich ,
Duilio Arigoni ,
Adelbert Bacher ,
Wolfgang Eisenreich
June 2002
June 2002
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Abstract
(E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate (E-6) was synthesized in six reaction
steps from hydroxyacetone (9) and (ethoxycarbonylmethenyl)-triphenylphosphorane (11)
with an overall yield of 38%. The compound was shown to be identical with the product
of IspG protein, which serves as an intermediate in the nonmevalonate terpene biosynthetic
pathway.