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ROS1 rearrangements define a unique molecular class of lung cancers.
Kristin Bergethon
1 ,
Alice T Shaw ,
Sai-Hong Ignatius Ou ,
Ryohei Katayama ,
Christine M Lovly ,
Nerina T McDonald ,
Pierre P Massion ,
Christina Siwak-Tapp ,
Adriana Gonzalez ,
Rong Fang ,
Eugene J Mark ,
Julie M Batten ,
Haiquan Chen ,
Keith D Wilner ,
Eunice L Kwak ,
Jeffrey W Clark ,
David P Carbone ,
Hongbin Ji ,
Jeffrey A Engelman ,
Mari Mino-Kenudson ,
William Pao ,
A John Iafrate
Mar 10 2012
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Abstract
Chromosomal rearrangements involving the ROS1 receptor tyrosine kinase gene have recently been described in a subset of non-small-cell lung cancers (NSCLCs). Because little is known about these tumors, we examined the clinical characteristics and treatment outcomes of patients with NSCLC with ROS1 rearrangement.