3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A high density of tumor-infiltrating CD8 + T cells and CD20 + B cells correlates with prolonged survival in patients with a wide variety of human cancers, including high-grade serous ovarian carcinoma (HGSC). However, the potential impact of mature dendritic cells (DCs) in shaping the immune contexture of HGSC, their role in the establishment of T cell-dependent antitumor immunity, and their potential prognostic value for HGSC patients remain unclear. We harnessed immunohistochemical tests and biomolecular analyses to demonstrate that a high density of tumor-infiltrating DC-LAMP + DCs is robustly associated with an immune contexture characterized by T H1 polarization and cytotoxic activity. We showed that both mature DCs and CD20 + B cells play a critical role in the generation of a clinically-favorable cytotoxic immune response in HGSC microenvironment. In line with this notion, robust tumor infiltration by both DC-LAMP + DCs and CD20 + B cells was associated with most favorable overall survival in two independent cohorts of chemotherapy-naïve HGSC patients. Our findings suggest that the presence of mature, DC-LAMP + DCs in the tumor microenvironment may represent a novel, powerful prognostic biomarker for HGSC patients that reflects the activation of clinically-relevant anticancer immunity.

          Electronic supplementary material

          The online version of this article (10.1186/s40425-018-0446-3) contains supplementary material, which is available to authorized users.

          Related collections

          Most cited references20

          • Record: found
          • Abstract: found
          • Article: not found

          Decisions about dendritic cells: past, present, and future.

          A properly functioning adaptive immune system signifies the best features of life. It is diverse beyond compare, tolerant without fail, and capable of behaving appropriately with a myriad of infections and other challenges. Dendritic cells are required to explain how this remarkable system is energized and directed. I frame this article in terms of the major decisions that my colleagues and I have made in dendritic cell science and some of the guiding themes at the time the decisions were made. As a result of progress worldwide, there is now evidence of a central role for dendritic cells in initiating antigen-specific immunity and tolerance. The in vivo distribution and development of a previously unrecognized white cell lineage is better understood, as is the importance of dendritic cell maturation to link innate and adaptive immunity in response to many stimuli. Our current focus is on antigen uptake receptors on dendritic cells. These receptors enable experiments involving selective targeting of antigens in situ and new approaches to vaccine design in preclinical and clinical systems.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Control of Metastasis by NK Cells.

            The metastatic spread of malignant cells to distant anatomical locations is a prominent cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms that enable neoplastic cells to invade the local microenvironment, reach the circulation, and colonize distant sites, including the so-called epithelial-to-mesenchymal transition. Moreover, metastasis is regulated by microenvironmental and systemic processes, such as immunosurveillance. Here, we outline the cancer-cell-intrinsic and -extrinsic factors that regulate metastasis, discuss the key role of natural killer (NK) cells in the control of metastatic dissemination, and present potential therapeutic approaches to prevent or target metastatic disease by harnessing NK cells.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

              Summary Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic competence was afforded by chromosome complexity, and we identify 9p loss as a highly selected event driving metastasis and ccRCC-related mortality (p = 0.0014). Distinct patterns of metastatic dissemination were observed, including rapid progression to multiple tissue sites seeded by primary tumors of monoclonal structure. By contrast, we observed attenuated progression in cases characterized by high primary tumor heterogeneity, with metastatic competence acquired gradually and initial progression to solitary metastasis. Finally, we observed early divergence of primitive ancestral clones and protracted latency of up to two decades as a feature of pancreatic metastases.
                Bookmark

                Author and article information

                Contributors
                fucikova@sotio.com
                Journal
                J Immunother Cancer
                J Immunother Cancer
                Journal for Immunotherapy of Cancer
                BioMed Central (London )
                2051-1426
                4 December 2018
                4 December 2018
                2018
                : 6
                : 139
                Affiliations
                [1 ]ISNI 0000 0004 1937 116X, GRID grid.4491.8, Department of Immunology, , Charles University, 2nd Faculty of Medicine and University Hospital Motol, ; Prague, Czech Republic
                [2 ]GRID grid.476702.0, Sotio, ; Prague, Czech Republic
                [3 ]ISNI 0000 0004 1937 116X, GRID grid.4491.8, Department of Pathology and Molecular Medicine, , Charles University, 2nd Faculty of Medicine and University Hospital Motol, ; Prague, Czech Republic
                [4 ]ISNI 0000 0004 1937 116X, GRID grid.4491.8, The Fingerland Department of Pathology, , Charles University, Faculty of Medicine and University Hospital Hradec Kralove, ; Hradec Kralove, Czech Republic
                [5 ]ISNI 0000 0004 1937 116X, GRID grid.4491.8, Department of Gynecology and Obstetrics, , Charles University, Faculty of Medicine and University Hospital Hradec Kralove, ; Hradec Kralove, Czech Republic
                [6 ]ISNI 0000 0004 1937 116X, GRID grid.4491.8, Department of Gynecology and Obstetrics, , Charles University, 3rd Faculty of Medicine and University Hospital Kralovske Vinohrady, ; Prague, Czech Republic
                [7 ]ISNI 0000 0004 1937 116X, GRID grid.4491.8, Department of Gynecology and Obstetrics, , Charles University, 2nd Faculty of Medicine and University Hospital Motol, ; Prague, Czech Republic
                [8 ]GRID grid.417925.c, INSERM, U1138, Centre de Recherche des Cordeliers, ; Paris, France
                [9 ]ISNI 0000 0001 2308 1657, GRID grid.462844.8, Sorbonne Université, ; Paris, France
                [10 ]ISNI 0000 0001 2188 0914, GRID grid.10992.33, Université Paris Descartes/Paris V, ; Paris, France
                [11 ]ISNI 000000041936877X, GRID grid.5386.8, Department of Radiation Oncology, , Weill Cornell Medical College, ; New York, NY USA
                [12 ]Sandra and Edward Meyer Cancer Center, New York, NY USA
                Article
                446
                10.1186/s40425-018-0446-3
                6288908
                30526667
                f0433ffa-45c1-4417-ad4d-b587db4cce45
                © The Author(s). 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 26 October 2018
                : 8 November 2018
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2018

                dendritic cells,dc-lamp,cd8+ cytotoxic t lymphocytes,natural killer cells,tertiary lymphoid structures

                Comments

                Comment on this article