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      The genetics of mammalian circadian order and disorder: implications for physiology and disease.

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          Abstract

          Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The genetic basis of circadian rhythms is well studied in model organisms and, more recently, studies of the genetic basis of circadian disorders has confirmed the conservation of key players in circadian biology from invertebrates to humans. In addition, important advances have been made in understanding how these molecules influence physiological functions in tissues throughout the body. Together, these studies set the scene for applying our knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.

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          Author and article information

          Journal
          Nat Rev Genet
          Nature reviews. Genetics
          Springer Science and Business Media LLC
          1471-0064
          1471-0056
          Oct 2008
          : 9
          : 10
          Affiliations
          [1 ] Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois 60208-3520, USA. j-takahashi@northwestern.edu
          Article
          nrg2430 NIHMS503915
          10.1038/nrg2430
          3758473
          18802415
          f046c8a3-5e30-4cb6-8ad6-cef35f236cdf
          History

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