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      Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder

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          Abstract

          <p class="first" id="d3224851e269">An important challenge in mental health research is to translate findings from cognitive neuroscience and neuroimaging research into effective treatments that target the neurobiological alterations involved in psychiatric symptoms. To address this challenge, in this review we propose a heuristic neurocircuit-based taxonomy to guide the treatment of obsessive-compulsive disorder (OCD). We do this by integrating information from several sources. First, we provide case vignettes in which patients with OCD describe their symptoms and discuss different clinical profiles in the phenotypic expression of the condition. Second, we link variations in these clinical profiles to underlying neurocircuit dysfunctions, drawing on findings from neuropsychological and neuroimaging studies in OCD. Third, we consider behavioral, pharmacological, and neuromodulatory treatments that could target those specific neurocircuit dysfunctions. Finally, we suggest methods of testing this neurocircuit-based taxonomy as well as important limitations to this approach that should be considered in future research. </p>

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          Journal
          Molecular Psychiatry
          Mol Psychiatry
          Springer Science and Business Media LLC
          1359-4184
          1476-5578
          January 07 2021
          Article
          10.1038/s41380-020-01007-8
          8260628
          33414496
          f05527e7-d7de-4386-b78d-6a93570f26a3
          © 2021

          http://www.springer.com/tdm

          http://www.springer.com/tdm


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