Evaluation of Hypertonic Peritoneal Dialysis Solutions with Low Sodium

Abstract

19 separate 3- to 5-day ultrafiltration peritoneal dialyses (UPD) were performed in 12 markedly edematous patients. A 7-percent dextrose dialysis solution with 120 mEq/l sodium (7–120) was used in 10 dialyses and 4.5% dextrose with 130 mEq/l sodium (4.5–130) in 9 dialyses. Each exchange was cycled every 2 h. Daily negative balance of 3–41 was achieved. Predialysis and postdialysis serum sodium concentration was 136 ± 7 mEq/l (mean ± l SD), 135 ± 5 with 7–120 and 139 ± 7, 137 ± 4 with 4.5–130. Predialysis and postdialysis serum chloride was 103 ± 6mEq/l, 106 ± 9 with 7–120 and 108 ± 6, 108 ± 5 with 4.5–130. The ratio of sodium concentration in ultra-filtrate to the serum sodium (SC_Na) was 0.92 ± 0.13 with 7–120 and 0.96 ± 0.12 with 4.5–130. There was a positive correlation between serum sodium and SC_Na and a negative correlation between ultrafiltration volume and SCNa with both the solutions. No clinical complications were noted. The data suggest that hypernatremia is avoided in UPD with 7–120 and 4.5–130 with 2-hour exchange. The exclusive use of these solutions is relatively safe and does not result in hyponatremia during UPD in edematous patients.