Blog
About

19
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

      Nature medicine

      physiology, drug effects, Signal Transduction, Physical Conditioning, Animal, Mice, Transgenic, Mice, Inbred C57BL, Mice, Male, pharmacology, metabolism, genetics, antagonists & inhibitors, Interleukin-6, secretion, Insulin, Humans, Glucose Tolerance Test, Glucagon-Secreting Cells, Glucagon-Like Peptide 1, Female, Enteroendocrine Cells, Disease Models, Animal, Diet, High-Fat, physiopathology, Diabetes Mellitus, Type 2, Cells, Cultured, Blood Glucose, Animals

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Exercise, obesity and type 2 diabetes are associated with elevated plasma concentrations of interleukin-6 (IL-6). Glucagon-like peptide-1 (GLP-1) is a hormone that induces insulin secretion. Here we show that administration of IL-6 or elevated IL-6 concentrations in response to exercise stimulate GLP-1 secretion from intestinal L cells and pancreatic alpha cells, improving insulin secretion and glycemia. IL-6 increased GLP-1 production from alpha cells through increased proglucagon (which is encoded by GCG) and prohormone convertase 1/3 expression. In models of type 2 diabetes, the beneficial effects of IL-6 were maintained, and IL-6 neutralization resulted in further elevation of glycemia and reduced pancreatic GLP-1. Hence, IL-6 mediates crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand. This previously unidentified endocrine loop implicates IL-6 in the regulation of insulin secretion and suggests that drugs modulating this loop may be useful in type 2 diabetes.

          Related collections

          Author and article information

          Journal
          22037645
          4286294
          10.1038/nm.2513

          Comments

          Comment on this article