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      Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production

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          Abstract

          Four new triterpene saponins, mandshunosides F-I ( 1–4), together with five known compounds ( 5–9), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis products. Bisdesmosidic saponin ( 3–9) showed modest suppression of NO production with the inhibition ratios in the range of 51.3%–64.6% at 50 μmol·L –1, whereas monodesmosidic saponins with a free carboxyl group at C-28 ( 1 and 2) showed potent inhibitory activities with IC 50 values being 12.7 and 8.3 μmol·L –1, respectively.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 February 2017
          : 16
          : 2
          : 131-138
          Affiliations
          1College of Pharmacy and Biological Engineering, Chengdu University, Chengdu 610106, China
          Author notes
          *Corresponding author: FU Qiang, E-mail: peter028@ 123456126.com

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30039-6
          10.1016/S1875-5364(18)30039-6
          Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81503234
          This work was supported by the National Natural Science Foundation of China (No. 81503234).

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