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      Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana

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          Abstract

          Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids, cathayanalactones A−F ( 16), together with seven analogues ( 713). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1, 2, 3, 7 and 11 showed inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier BV
          1875-5364
          20 December 2019
          : 17
          : 12
          : 953-962
          Affiliations
          1 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
          Author notes
          *Corresponding author: ZHANG Xing-Jie, Tel: 86-871-65223251, E-mails: zhangxj@ 123456ynu.edu.cn , XIAO Wei-Lie, xiaoweilie@ 123456ynu.edu.cn

          Δ These authors contributed equally to this work.

          These authors have no conflict of interest to declare.

          Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday

          Article
          S1875-5364(19)30118-9
          10.1016/S1875-5364(19)30118-9
          31882051
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Yunnan Applicative and Basic Research Program
          Award ID: 2018FY001
          Funded by: Yunnan Applicative and Basic Research Program
          Award ID: 2018FA048
          Funded by: National Natural Science Foundation of China
          Award ID: 81422046
          Funded by: National Natural Science Foundation of China
          Award ID: 81860615
          Funded by: National Natural Science Foundation of China
          Award ID: 21762048
          Funded by: Foundation of Yunnan Educational Committee
          Award ID: 2018JS002
          Funded by: Natural Science Foundation of Yunnan University
          Award ID: 2017YDQN03
          Funded by: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education
          Award ID: 2017KF02
          Funded by: Program for Changjiang Scholars and Innovative Research Team in University
          Award ID: IRT_17R94
          Funded by: Project of Innovative Research Team of Yunnan Province to XIAO Wei-Lie
          Award ID:
          This work was supported by Yunnan Applicative and Basic Research Program (Nos. 2018FY001 and 2018FA048), the National Natural Science Foundation of China (Nos. 81422046, 81860615 and 21762048), the Foundation of Yunnan Educational Committee (No. 2018JS002), the Natural Science Foundation of Yunnan University (No. 2017YDQN03), the Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education (No. 2017KF02), the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT_17R94), and Project of Innovative Research Team of Yunnan Province to XIAO Wei-Lie.
          Categories
          Research article

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