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      Impact of solid state miscibility on quantitive nano-precipitation of budesonide and PVP-VA.

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      British Journal of Pharmacy

      University of Huddersfield Press

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          Abstract

          In the present study, the drug–polymer miscibility and molecular interaction of budesonide in polymers (PVP/VA E 735, 635 and 535) systems were studied, by using three techniques including, calculation of Hansen solubility parameters, analysis of melting points depression, and measurement of glass transition temperature (Tg). Budesonide nanoparticles were prepared by sonication technique.  The combined effect of four significant formulation variables, namely, polymer and surfactant concentrations, time and amplitude of sonication on particle size, polydispersity, drug loading and entrapment efficiency of drug was investigated by apply 24 factorial design. The drug/ polymer blend was considered miscible depending on the results of three approaches. The results of calculated values of miscibility parameter (χ) for each pair were negative ranging from - 2.012to -1.948. Single Tg and positive deviation from Gordon-Taylor model for all ratios of drug–polymer binary mixtures. Produced amorphous budesonide nanoparticles, depending on choice of polymer and process parameters contained from 97% to 99% drug, with particle size diameter varying in size from 641-357 nm. It was found that clear evidence on effect VA ratio on percent entrapment efficiency and particle size of budesonide. 

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          Author and article information

          Journal
          British Journal of Pharmacy
          University of Huddersfield Press
          2058-8356
          April 3 2019
          April 3 2019
          : 4
          : 1
          Article
          10.5920/bjpharm.606
          © 2019

          This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

          Medicine, Pharmacology & Pharmaceutical medicine, Health & Social care

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