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      Breast cancer metastasis: markers and models.

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          Abstract

          Breast cancer starts as a local disease, but it can metastasize to the lymph nodes and distant organs. At primary diagnosis, prognostic markers are used to assess whether the transition to systemic disease is likely to have occurred. The prevailing model of metastasis reflects this view--it suggests that metastatic capacity is a late, acquired event in tumorigenesis. Others have proposed the idea that breast cancer is intrinsically a systemic disease. New molecular technologies, such as DNA microarrays, support the idea that metastatic capacity might be an inherent feature of breast tumours. These data have important implications for prognosis prediction and our understanding of metastasis.

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          Author and article information

          Journal
          Nat Rev Cancer
          Nature reviews. Cancer
          Springer Science and Business Media LLC
          1474-175X
          1474-175X
          Aug 2005
          : 5
          : 8
          Affiliations
          [1 ] Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
          Article
          nrc1670
          10.1038/nrc1670
          16056258
          f0892cd3-017e-4ee6-a3d4-3ed6bec95d15
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