Psychological distress during the COVID-19 pandemic amongst anaesthesiologists and nurses

Abstract

Editor The 2019 novel coronavirus disease (COVID-19) pandemic has overwhelmed healthcare systems worldwide, profoundly impacting the lives of anaesthesiologists, intensivists, and nurses caring for the critically ill. Such high-acuity patient care imposes a significant physical and cognitive burden, which is further compounded by increased workloads, staffing deficiencies, and equipment shortages. Participation in aerosol-generating procedures and frequent direct patient contact may increase risk of infection. Government-imposed containment measures may lead to social isolation and restrict access to usual coping mechanisms. Exposure to contagion may also engender concerns from staff living with the elderly and young children. The previous Severe Acute Respiratory Syndrome (SARS) outbreak of 2003 saw emotional exhaustion, anxiety, depression and burnout afflicting healthcare workers 1 , 2 . Similarly, studies on healthcare workers from China and Italy have described stress-related anxiety and depression during the COVID-19 pandemic 3 , 4 . These studies did not specifically examine intensive care providers, who may constitute a high-risk sub-group. We sought to determine the prevalence and severity of psychological distress amongst anaesthesiologists and nurses working in intensive care units during this pandemic, and identify potential risk factors. We also studied their main concerns, perceptions of pandemic-preparedness, training adequacy, and staff protection. This observational, cross-sectional study was conducted at a 1,240-bed tertiary academic medical centre in Singapore. During this pandemic, anaesthesiologists were rostered into intensive care units in our hospital. Ethics approval was obtained from the institutional domain-specific review board (DSRB: 2020/00648), prior to commencement of the study. All anaesthesiologists (including trainees) and nurses working in intensive care units were invited to participate with a one-time self-administered online questionnaire. The sampling period was 11 to 15 June 2020, during which Singapore saw 400 to 500 new cases daily, with a cumulative total exceeding 40,000 cases for a population of ∼ 5.8 million. Two survey completion reminders were issued. All participants completed a 46-question, closed-ended self-reporting questionnaire (Appendix 1). No identifying information was collected. The anonymised questionnaire collected participant characteristics, medical history, and workplace characteristics such as redeployment outside normal professional boundaries, direct COVID-19 patient care, workload during the pandemic, and availability of personal protective equipment (PPE). We also explored perceptions and concerns surrounding the COVID-19 pandemic, as well as direct impact of the COVID-19 pandemic, such as having received a quarantine order, or knowing someone diagnosed with COVID-19. Key mental health outcomes were measured using two validated self-reporting instruments for identifying psychological distress: the 12-item general health questionnaire (GHQ-12) and hospital anxiety and depression scale (HADS). Two instruments were used to provide additional information, classify the type of psychological distress, and detect inconsistent conclusions. The GHQ-12 comprises 12 items describing aspects of anxiety, depression and social functioning, with four possible responses each. Responses were coded and scored using a two-point response system 1 . A cut-off above 3 was used to identify psychological distress 1 , 5 . The HADS comprises 2 subscales: seven questions each for anxiety and depression 6 , scored using a 4-point Likert scale. Anxiety and depression were scored separately, and scores above 10 indicated moderate emotional distress 6 . Univariate analyses were performed to identify differences within participant characteristics. Multivariate logistic regression models were used for both GHQ-12 and HADS outcomes, to explore associations with the following variables: gender, occupation, work experience, marital status, knowing someone with diagnosed COVID-19, direct care of COVID-19 patients, redeployment outside usual professional boundaries, having been quarantined, and staff having more than one comorbid condition. Of 308 invited participants, a total of 270 anaesthesiologists (42.6%) and nurses (57.4%) responded. The response rate was 90.6% and 85.6% amongst anaesthesiologists and nurses, respectively. Appendix 2 describes participant characteristics. Most participants were female (70.7%), aged 25 to 35 yr (55.2%), with a majority (78.1%) directly involved in manging patients with COVID-19. The GHQ-12 identified psychological distress in 37.4% of respondents (median, 2.0; SD, 2.88) (Appendix 3). At least moderate anxiety was identified in 30.7% (median, 7.0; SD, 5.16), and depression in 30.0% of study participants (median 7.0; SD, 5.02) using the HADS (Table 1 ). One-fifth (20.4%) of participants showed both anxiety and depression, which was proportionately higher in nurses (13.7%) compared to anaesthesiologists (6.7%), although not statistically significant (ρ=0.097). Cronbach’s alpha values for the GHQ-12 (0.803) and HADS (0.934) showed satisfactory internal consistency. Statistically significant associations with psychological distress were found for the presence of multiple comorbidities in staff, direct involvement in COVID-19 patient care, receiving a quarantine order, and redeployment outside normal professional boundaries (Table 1). Insomnia, based on the first item of the GHQ-12, was reported by 45 participants (16.7%). Redeployment to work outside areas of usual clinical practice was reported by 41.9% of participants. The majority (59.3%) perceived their workload to be similar to pre-pandemic levels. Just 12.2% of participants had family, friends, or colleagues diagnosed with COVID-19. Formal PPE training was received by 256 (94.8%) participants with 149 (55.2%) being confident in correct usage and their ability to protect from infection. Situations where recommended PPE was unavailable were encountered by 46 (17.0%). Risks of getting infected (83.6%) and infecting family members (78.0%) were the top two concerns (Appendix 2). Table 1 Summary of the results of the Hospital Anxiety and Depression Scale, displaying unadjusted and adjusted odds ratios Table 1 Characteristic HADS-A* ρ value Unadjusted OR † (95% CI) Adjusted OR (95% CI) ρ value HADS-D ‡ ρ value Unadjusted OR (95% CI) Adjusted OR (95% CI) ρ value < 11 ≥ 11 < 11 ≥ 11 no. (%) no. (%) no. (%) no. (%) Overall 188 (69.6) 82 (30.4) 189 (70.0) 81 (30.0) Gender Male 63 (23.3) 16 (5.9) 0.020 1.0 1.0 0.060 57 (21.1) 22 (8.1) 0.620 1.0 1.0 0.325 Female 125 (46.2) 66 (24.4) 2.1 (1.1 – 3.9) 2.9 (1.3 – 6.1) 132 (48.9) 59 (21.9) 1.2 (0.6 – 2.0) 1.4 (0.7 – 2.8) Occupation Physician 85 (31.4) 30 (11.1) 0.187 1.0 1.0 0.772 83 (30.7) 32 (11.9) 0.502 1.0 1.0 0.770 Nurse 103 (38.1) 52 (19.2) 1.4 (0.8 – 2.4) 0.9 (0.5 – 1.8) 106 (39.3) 49 (18.1) 1.2 (0.7 – 2.0) 0.9 (0.5 – 1.8) Knew someone diagnosed with diagnosed with COVID-19 Yes 21 (7.8) 14 (5.2) 0.184 1.6 (0.8 – 3.4) 0.8 (0.3 – 1.9) 0.572 27 (10) 8 (3.0) 0.323 0.7 (0.3 – 1.5) 0.6 (0.2 – 1.5) 0.230 No 167 (61.9) 68 (25.2) 1.0 1.0 162 (60.0) 73 (27.0) 1.0 1.0 Treated a patient with COVID-19 Yes 139 (51.5) 72 (26.7) 0.011 2.5 (1.2 – 5.3) 2.9 (1.3 – 6.5) 0.011 143 (53.0) 68 (25.2) 0.131 1.7 (0.9 – 3.3) 1.5 (0.7 – 3.1) 0.265 No 49 (18.1) 10 (3.7) 1.0 1.0 46 (17.0) 13 (4.8) 1.0 1.0 Redeployed to areas outside of usual clinical practice Yes 71 (26.3) 42 (15.6) 0.039 1.7 (1.0 – 2.9) 1.6 (0.9 – 2.8) 0.124 71 (26.3) 42 (15.6) 0.029 1.8 (1.1 – 3.0) 1.8 (1.0 – 3.1) 0.042 No 117 (43.3) 40 (14.8) 1.0 1.0 118 (43.7) 71 (26.3) 1.0 1.0 Subject of a quarantine order or stay home notice Yes 18 (6.7) 21 (7.8) 0.001 3.3 (1.6 – 6.5) 3.6 (1.6 – 8.1) 0.020 29 (10.7) 10 (3.7) .521 0.8 (0.4 – 1.7) 0.7 (0.3 – 1.8) .487 No 170 (63.0) 61 (22.6) 1.0 1.0 160 (59.3) 71 (26.3) 1.0 1.0 More than one co-morbid condition Yes 8 (3.0) 11 (4.1) 0.007 3.5 (1.3 – 9.0) 3.2 (1.1 – 9.4) 0.030 8 (3.0) 11 (4.1) .006 3.6 (1.4 – 9.2) 4.7 (1.6 – 13.5) .005 No 180 (66.7) 71 (26.3) 1.0 1.0 181 (67.0) 70 (26.3) 1.0 1.0 Abbreviations: *HADS-A Hospital Anxiety and Depression Scale (Anxiety); †OR odds ratio; ‡HADS-D Hospital Anxiety and Depression Scale (Depression) This study shows significant psychological distress amongst anaesthesiologists and nurses working in intensive care units in the context of the COVID-19 pandemic. While lower than reported in the outbreak epicentre in China, which reported depression in 50.4% and anxiety in 44.6% of healthcare workers, we found a two-fold higher prevalence of anxiety and up to three-fold higher prevalence of depression than reported amongst general healthcare workers in Singapore and Italy during this pandemic 3 , 4 , 7 . Many would regard even pre-pandemic work in such high-acuity environments as stressful and emotionally exhausting, thus potentially accounting for the differences compared to general healthcare workers. Indeed, pre-pandemic studies of occupational stress identified similar levels of anxiety and stress (29.0% to 35.7%) in intensive care unit physicians and nurses using the GHQ-125,8. Thus, the contention that COVID-19 has provoked all the elements of psychological distress in respondents still requires testing. Our study has limitations. Socioeconomic status, which may influence outcomes and intervention planning, was not assessed. Neither a pre-crisis baseline nor follow-up to assess the temporal changes in psychological distress were available. Being a single-centre snapshot, further studies in other populations are necessary for generalisability. Lastly, clinical interviews by a psychiatrist would have been ideal. Nonetheless, we identified risk factors for psychological distress that may be useful for identifying at-risk individuals, and respondent concerns of the infection risk, adequacy of PPE, as well as redeployment outside normal professional boundaries are still issues which need to be addressed. The psychological distress prevalent amongst providing anaesthesia and intensive care providers during this pandemic necessitates policies for screening of at-risk individuals, and adoption of early psychological support interventions for affected staff 9 , 10 . Authors’ contributions CCML conceived the study design and drafted the manuscript. All authors were involved in data collection and analysis. All authors critically reviewed and edited the manuscript. Declaration of interests The authors declare no competing interests. Uncited reference 8..