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      Idiopathic Membranous Nephropathy, Associated with HLA-DRw3 and Not Related to Monocyte-Phagocyte System Fc Receptor Dysfunction, in Father and Son

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          Familial idiopathic membranous nephropathy, an immune-complex-associated glomerulopathy, has not been previously reported in father and son, despite its striking immunogenetic correlation, especially with HLA-DR3. As a dysfunction of the monocyte-phagocyte system (MPS), it has been observed linked to DR3 antigen, so we studied the MPS Fc receptor function in a father and his son with a histologically proven membranous nephropathy, associated with the haplotype A9-B35-DR3-DQw2. The Fc receptor function of the MPS was examined by measuring the clearance of IgG-sensitized, <sup>51</sup>Cr-labeled erythrocytes and by measuring the ability of isolated monocytes to ingest autologous red blood cells coated with IgG anti-Rh (D) antibody. Immune clearance and in vitro phagocytosis was normal in both patients and not related to their levels of immune complexes (as measured by ELISA Clq and Conglutinin solid-phase binding assay). This report suggest that genetic factors may play an important role in the development of membranous nephropathy, and it seems not to be related to a dysfunction of MPS as measured by these tests.

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          Author and article information

          S. Karger AG
          11 December 2008
          : 58
          : 3
          : 320-324
          aRenal Division, School of Medicine, Universidad Austral, Valdivia, Chile; bInstituto Salud Pública, Santiago, Chile
          186444 Nephron 1991;58:320–324
          © 1991 S. Karger AG, Basel

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          Pages: 5
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