Lipid Response to Female Gonadal Hormones of Female Rats Fed a High Glucose or a High Fructose Diet

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Abstract

Sexually mature female rats were given, for 11 weeks, diets high in fructose or glucose and at the same time oestrogen and progestogen were administered both singly and together. Analysis of the lipids in the liver, serum and adipose tissue was carried out after ingestion of <sup>14</sup>C-fructose or glucose. Oestrogen lowered the liver triglyceride level but raised the serum triglyceride concentration. Progestogen tended to raise both cholesterol and triglyceride levels in liver and serum and it also caused a greater increase in body weight than in control or in the oestrogen animals. An increased specific activity was seen at first in the adipose tissue of the glucose-fed rats receiving the hormones. Overall, there was a tendency for the female gonadal hormones to exaggerate the changes brought about by the high carbohydrate diets.

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Journal

Journal ID (publisher-id): ANM

Journal ID (nlm-ta): Ann Nutr Metab

Journal ID (doi): 10.1159/issn.0250-6807

Title: Annals of Nutrition and Metabolism

Publisher: S. Karger AG

ISSN (Print): 0250-6807

ISSN (Electronic): 1421-9697

Publication date Subscription-year: 1975

Publication date (Print): 1975

Publication date (Electronic): 13 November 2008

Volume: 19

Issue: 3-4

Pages: 212-222

Affiliations

Department of Physiology, Guys Hospital Medical School, London

Article

Publisher ID: 175665 Other ID: Nutr Metab 1975;19:212–222

DOI: 10.1159/000175665

SO-VID: f09a0e1f-2549-495a-9d11-e533c87c5a76

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 02 June 1975

Date accepted : 06 October 1975

Page count

Pages: 11

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