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      Culex mosquitoes are experimentally unable to transmit Zika virus

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          Abstract

          We report that two laboratory colonies of Culex quinquefasciatus and Culex pipiens mosquitoes were experimentally unable to transmit ZIKV either up to 21 days post an infectious blood meal or up to 14 days post intrathoracic inoculation. Infectious viral particles were detected in bodies, heads or saliva by a plaque forming unit assay on Vero cells. We therefore consider it unlikely that Culex mosquitoes are involved in the rapid spread of ZIKV.

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          First report of autochthonous transmission of Zika virus in Brazil

          Camila Zanluca, Vanessa de Melo, Ana Mosimann … (2015)
          In the early 2015, several cases of patients presenting symptoms of mild fever, rash, conjunctivitis and arthralgia were reported in the northeastern Brazil. Although all patients lived in a dengue endemic area, molecular and serological diagnosis for dengue resulted negative. Chikungunya virus infection was also discarded. Subsequently, Zika virus (ZIKV) was detected by reverse transcription-polymerase chain reaction from the sera of eight patients and the result was confirmed by DNA sequencing. Phylogenetic analysis suggests that the ZIKV identified belongs to the Asian clade. This is the first report of ZIKV infection in Brazil.
          Article 0 comments Cited 509 times – based on 0 reviews     Review now
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            Differential Susceptibilities of Aedes aegypti and Aedes albopictus from the Americas to Zika Virus

            Thais Chouin-Carneiro, Anubis Vega-Rúa, Marie Vazeille … (2016)
            Background Since the major outbreak in 2007 in the Yap Island, Zika virus (ZIKV) causing dengue-like syndromes has affected multiple islands of the South Pacific region. In May 2015, the virus was detected in Brazil and then spread through South and Central America. In December 2015, ZIKV was detected in French Guiana and Martinique. The aim of the study was to evaluate the vector competence of the mosquito spp. Aedes aegypti and Aedes albopictus from the Caribbean (Martinique, Guadeloupe), North America (southern United States), South America (Brazil, French Guiana) for the currently circulating Asian genotype of ZIKV isolated from a patient in April 2014 in New Caledonia. Methodology/Principal Findings Mosquitoes were orally exposed to an Asian genotype of ZIKV (NC-2014-5132). Upon exposure, engorged mosquitoes were maintained at 28°±1°C, a 16h:8h light:dark cycle and 80% humidity. 25–30 mosquitoes were processed at 4, 7 and 14 days post-infection (dpi). Mosquito bodies (thorax and abdomen), heads and saliva were analyzed to measure infection, dissemination and transmission, respectively. High infection but lower disseminated infection and transmission rates were observed for both Ae. aegypti and Ae. albopictus. Ae. aegypti populations from Guadeloupe and French Guiana exhibited a higher dissemination of ZIKV than the other Ae. aegypti populations examined. Transmission of ZIKV was observed in both mosquito species at 14 dpi but at a low level. Conclusions/Significance This study suggests that although susceptible to infection, Ae. aegypti and Ae. albopictus were unexpectedly low competent vectors for ZIKV. This may suggest that other factors such as the large naïve population for ZIKV and the high densities of human-biting mosquitoes contribute to the rapid spread of ZIKV during the current outbreak.
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              Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia.

              R. García, N J Marchette, A. Rudnick (1969)
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                Author and article information

                Journal
                Journal ID (nlm-ta): Euro Surveill
                Journal ID (iso-abbrev): Euro Surveill
                Journal ID (publisher-id): ES
                Title: Eurosurveillance
                Publisher: European Centre for Disease Prevention and Control (ECDC)
                ISSN (Print): 1025-496X
                ISSN (Electronic): 1560-7917
                Publication date (Print): 01 September 2016
                Volume: 21
                Issue: 35
                Electronic Location Identifier: 30333
                Affiliations
                [1 ]Institut Pasteur, Arboviruses and Insect Vectors, Department of Virology, Paris, France
                [2 ]These authors contributed equally to this manuscript
                [3 ]Institut Pasteur of Guadeloupe, Laboratory of Medical Entomology, Environment and Health Unit, Les Abymes, Guadeloupe
                [4 ]Instituto Oswaldo Cruz, Laboratório de Mosquitos Transmissores de Hematozoários, Rio de Janeiro, Brazil
                Author notes

                Correspondence: Anna-Bella Failloux ( anna-bella.failloux@ 123456pasteur.fr )

                Article
                Publisher ID: 16-00558 Publisher ID: 30333
                DOI: 10.2807/1560-7917.ES.2016.21.35.30333
                PMC ID: 5015461
                PubMed ID: 27605159
                SO-VID: f09b2d16-80f7-459a-8994-f4639392f1a2
                Copyright © This article is copyright of The Authors, 2016.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.

                History
                Date received : 16 August 2016
                Date accepted : 01 September 2016
                Categories
                Subject: Rapid Communication

                Keywords: zika,culex mosquitoes,vector competence
                Data availability:
                Keywords: zika, culex mosquitoes, vector competence

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