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      Cancer genes and the pathways they control.

      1 ,
      Nature medicine
      Springer Science and Business Media LLC

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          Abstract

          The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation.

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          Author and article information

          Journal
          Nat Med
          Nature medicine
          Springer Science and Business Media LLC
          1078-8956
          1078-8956
          Aug 2004
          : 10
          : 8
          Affiliations
          [1 ] Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA. vogelbe@welch.jhu.edu
          Article
          nm1087
          10.1038/nm1087
          15286780
          f09ebdc7-5c5b-47e6-b88d-cc055801b55a
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