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      Cancer genes and the pathways they control.

      Nature medicine

      metabolism, Tumor Suppressor Protein p53, Transcription Factors, Trans-Activators, Smad Proteins, physiology, genetics, Signal Transduction, Retinoblastoma Protein, Receptor Protein-Tyrosine Kinases, Phosphatidylinositol 3-Kinases, Oncogenes, Nuclear Proteins, Neoplasms, Mutation, Hypoxia-Inducible Factor 1, alpha Subunit, Hypoxia-Inducible Factor 1, Humans, Genes, Tumor Suppressor, DNA-Binding Proteins, DNA Repair, Apoptosis, Adenomatous Polyposis Coli Protein

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          Abstract

          The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation.

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          Journal
          10.1038/nm1087
          15286780

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