MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that can modulate mRNA expression. Insights into the roles of miRNAs in development and disease have led to the development of new therapeutic approaches that are based on miRNA mimics or agents that inhibit their functions (antimiRs), and the first such approaches have entered the clinic. This Review discusses the role of different miRNAs in cancer and other diseases, and provides an overview of current miRNA therapeutics in the clinic.

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Journal

Title: Nature Reviews Drug Discovery

Abbreviated Title: Nat Rev Drug Discov

Publisher: Springer Nature

ISSN (Print): 1474-1776

ISSN (Electronic): 1474-1784

Publication date Created: February 17 2017

Publication date (Print): February 17 2017

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Article

DOI: 10.1038/nrd.2016.246

PubMed ID: 28209991

SO-VID: f0ad2729-340e-4b6c-96ee-2c69ebf937aa

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