Blog
About

0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Premature cardiovascular disease in chronic renal failure.

      Lancet

      Risk Factors, Research Design, adverse effects, Renal Dialysis, blood, Lipoprotein(a), metabolism, complications, Kidney Failure, Chronic, Humans, Homocysteine, Cholesterol, LDL, Cholesterol, HDL, Cause of Death, prevention & control, etiology, epidemiology, Cardiovascular Diseases, Anemia, Acute-Phase Proteins

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          There is a remarkable lack of reliable information about the determinants of risk of cardiovascular disease (CVD) among patients with chronic renal failure. Indeed, such patients have often been deliberately excluded from randomised trials of treatments of CVD, perhaps because of concerns about drug safety. But the absolute risk of CVD among them may be large, so the potential absolute benefits of treatments may also be large, and may well exceed any increased hazards. Hence, as well as further investigation of the underlying mechanisms of cardiac disease, it would be helpful to have some large-scale randomised trials in a wide range of renal patients of interventions (such as cholesterol-lowering drugs, antihypertensives, aspirin, B-vitamins, and antioxidant vitamins) that are of proven or suspected benefit in other settings. If safe and effective treatments can be identified, and started early in the natural history of renal failure, the exceptionally high risk of CVD experienced by these patients could be decreased before and after end-stage renal failure has occurred.

          Related collections

          Author and article information

          Journal
          10.1016/S0140-6736(00)02456-9
          10963260

          Comments

          Comment on this article