Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients

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Abstract

SARS-CoV-2 proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. 11 of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day one after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of IgG and IgA.

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Author and article information

Journal

Journal ID (nlm-ta): Clin Infect Dis

Journal ID (iso-abbrev): Clin Infect Dis

Journal ID (publisher-id): cid

Title: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

Publisher: Oxford University Press (US )

ISSN (Print): 1058-4838

ISSN (Electronic): 1537-6591

Publication date (Electronic): 20 May 2021

Publication date PMC-release: 20 May 2021

Electronic Location Identifier: ciab465

Affiliations

[1 ]Department of Pathology, Brigham and Women’s Hospital, Boston , MA, USA

[2 ]Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston , MA, USA

[3 ]Harvard Medical School, Boston , MA, USA

[4 ]Division of Infectious Diseases, Brigham and Women’s Hospital, Boston , MA, USA

[5 ]Division of Infectious Diseases, Centre Hospitalier de l’Université de Montréal , Montreal, QC, Canada

[6 ]Center for Clinical Investigation, Brigham and Women’s Hospital, Boston , MA, USA

Author notes

Corresponding author: David R. Walt, email: dwalt@ 123456bwh.harvard.edu

These author contributed equally

These authors contributed equally

Article

Publisher ID: ciab465

DOI: 10.1093/cid/ciab465

PMC ID: 8241425

PubMed ID: 34015087

SO-VID: f0cb261d-a231-405e-89e5-ae220b4d1cc2

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