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      Effects of flavonol quercetin on activity of lipid peroxide oxidation in experimental bacterial-immune periodontitis

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          Abstract

          The article presents the results of lipid peroxidation activity in blood serum, which were assessed on the base changes in the level of oxidative modification of proteins, TBA-active products, and total amount of nitrogen (II) oxide metabolites (NO 2 − + NO 3 −). Indices were determined on the 14 th day of development in experimental periodontitis both without correction, and in condition treatment with a water-soluble flavonol quercetin (corvitin). The treated animals take intramuscular injections of corvitin in a dose 100 mg/kg weight for 7 days. For further testing, blood serum was selected. The results were statistically analyzed using parametric and non-parametric indices. In this investigation, characterized dynamics of changes in the indices of oxidative processes activity were revealed both during the period of formation and the course of periodontitis. In particular, it was found that, for the period of the most expressed inflammatory reaction in the periodontal complex, intensive increase in the level of reactive forms of oxygen. The treatment with flavonol quercetin for 7 days resulted in stabilization of free radical processes and the suppression of the inflammatory reaction.

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          Flavonoids: antioxidants or signalling molecules?

          Robert J P Williams, Jeremy Spencer, Catherine Rice-Evans (2004)
          Many studies are accumulating that report the neuroprotective, cardioprotective, and chemopreventive actions of dietary flavonoids. While there has been a major focus on the antioxidant properties, there is an emerging view that flavonoids, and their in vivo metabolites, do not act as conventional hydrogen-donating antioxidants but may exert modulatory actions in cells through actions at protein kinase and lipid kinase signalling pathways. Flavonoids, and more recently their metabolites, have been reported to act at phosphoinositide 3-kinase (PI 3-kinase), Akt/protein kinase B (Akt/PKB), tyrosine kinases, protein kinase C (PKC), and mitogen activated protein kinase (MAP kinase) signalling cascades. Inhibitory or stimulatory actions at these pathways are likely to affect cellular function profoundly by altering the phosphorylation state of target molecules and by modulating gene expression. A clear understanding of the mechanisms of action of flavonoids, either as antioxidants or modulators of cell signalling, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anticancer agents, cardioprotectants, and inhibitors of neurodegeneration
          Article 0 comments Cited 419 times – based on 0 reviews     Review now
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            Biofilm dispersal: mechanisms, clinical implications, and potential therapeutic uses.

            J Kaplan (2010)
            Like all sessile organisms, surface-attached communities of bacteria known as biofilms must release and disperse cells into the environment to colonize new sites. For many pathogenic bacteria, biofilm dispersal plays an important role in the transmission of bacteria from environmental reservoirs to human hosts, in horizontal and vertical cross-host transmission, and in the exacerbation and spread of infection within a host. The molecular mechanisms of bacterial biofilm dispersal are only beginning to be elucidated. Biofilm dispersal is a promising area of research that may lead to the development of novel agents that inhibit biofilm formation or promote biofilm cell detachment. Such agents may be useful for the prevention and treatment of biofilms in a variety of industrial and clinical settings. This review describes the current status of research on biofilm dispersal, with an emphasis on studies aimed to characterize dispersal mechanisms, and to identify environmental cues and inter- and intracellular signals that regulate the dispersal process. The clinical implications of biofilm dispersal and the potential therapeutic applications of some of the most recent findings will also be discussed.
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              Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease.

              Sarah L Miles, Margaret M. McFarland, Richard M. Niles (2014)
              There is a growing realization that natural products such as phytochemicals can be used in diets or as supplements to prevent or treat human disease. The disciplines of epidemiology, pharmacognosy, and molecular biology have provided evidence that certain dietary constituents decrease blood pressure, influence immune and neuronal function, affect the incidence of cancer, and ameliorate the abnormal properties of cancer cells. Molecular studies have uncovered the interesting feature that most phytochemicals have multiple modes of action. This review focuses on the flavonoid phytochemical quercetin and describes the myriad of conditions in which quercetin affects a number of physiological processes. Despite the compelling information available, including a number of animal studies, translation of these findings into human clinical trials has been slow. The status of current clinical research on quercetin is summarized, and direction for further research is suggested. © 2014 International Life Sciences Institute.
              Article 0 comments Cited 37 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Interv Med Appl Sci
                Journal ID (iso-abbrev): Interv Med Appl Sci
                Journal ID (pmc): imas
                Journal ID (publisher-id): IMAS
                Title: Interventional Medicine & Applied Science
                Publisher: Akadémiai Kiadó (Budapest )
                ISSN (Print): 2061-1617
                ISSN (Electronic): 2061-5094
                Publication date (Electronic, pub): 19 December 2018
                Publication date (Print, pub): March 2019
                Volume: 11
                Issue: 1
                Pages: 55-59
                Affiliations
                [1 ]Department of Prosthetic Dentistry, Ivan Horbachevsky Ternopil State Medical University , Ternopil, Ukraine
                Author notes
                [* ]Corresponding address: Andrii Demkovych, PhD, Associate Professor; Department of Prosthetic Dentistry, Ivan Horbachevsky Ternopil State Medical University, Chehova str., 7, Ternopil 46000, Ukraine; Phone: +380 979 342501; Fax: +380 352 524183; E-mail: demkovushae@ 123456tdmu.edu.ua
                Article
                DOI: 10.1556/1646.10.2018.48
                PMC ID: 7044562
                SO-VID: f0e6b1aa-c5ad-4543-adf1-d3187d081803
                Copyright © © 2018 The Author(s)
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.

                History
                Date received : 26 February 2018
                Date revision received : 21 March 2018
                Date accepted : 10 October 2018
                Page count
                Figures: 3, Tables: 2, Equations: 0, References: 20, Pages: 5
                Funding
                Funding sources: No financial support was received for this study.
                Categories
                Subject: Original Paper

                Keywords: periodontitis,quercetin,tba-active products,nitrogen (ii) oxide,oxidative modification of proteins
                Data availability:
                Keywords: periodontitis, quercetin, tba-active products, nitrogen (ii) oxide, oxidative modification of proteins

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