Sildenafil in severe pulmonary hypertension associated with chronic obstructive pulmonary disease: A randomized controlled multicenter clinical trial.

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Abstract

Pulmonary hypertension (PH) is a well-known independent prognostic factor in chronic obstructive pulmonary disease (COPD) and a sufficient criterion for lung transplant candidacy. Limited data are currently available on the hemodynamic and clinical effect of phosphodiesterase 5 inhibitors in patients with severe PH associated with COPD. This study assessed the effect of sildenafil on pulmonary hemodynamics and gas exchange in severe PH associated with COPD.

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Journal

Journal ID (iso-abbrev): J. Heart Lung Transplant.

Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Publisher: Elsevier BV

ISSN (Electronic): 1557-3117

ISSN (Print): 1053-2498

Publication date (Electronic): Feb 2017

Volume: 36

Issue: 2

Affiliations

[1 ] Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, Italy.

[2 ] I Respiratory Disease Clinic, Department Of Clinical Medicine and Surgery, Federico II University, Naples, Italy.

[3 ] Department of Pneumology and Respiratory Intermediate Care Unit, University Hospital of Cattinara, Trieste, Italy.

[4 ] Division of Pneumology, Department of Internal Medicine, Città Della Salute e Della Scienza, Turin, Italy.

[5 ] Pulmonology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

[6 ] Department of Medical and Surgical Sciences & Neurosciences, University of Siena, Siena, Italy.

[7 ] Pulmonary Clinic Unit, San Gerardo Hospital, University of Milano Bicocca, Monza, Italy.

[8 ] Office of Research, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Mediterraneo per I Trapianti e Terapie ad Alta Specializzazione, Palermo, Italy.

[9 ] Pulmonary Hypertension Unit, Department of Cardiovascular and Respiratory Disease, Sapienza University of Rome, Italy.

[10 ] Centro Studi AIPO, Italian Association of Hospital Pneumologists, Milan, Italy.

[11 ] Department of Cardiology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

[12 ] Department of Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy.

[13 ] Pulmonary Hypertension Unit, Department of Cardiovascular and Respiratory Disease, Sapienza University of Rome, Italy. Electronic address: dario.vizza@uniroma1.it.

Article

Publisher Item ID: S1053-2498(16)30114-0

DOI: 10.1016/j.healun.2016.04.010

PubMed ID: 27329400

SO-VID: f0f09a3f-3770-4107-85ae-f17397383d87

History

Keywords: lung transplantation,sildenafil,pulmonary hypertension,end-stage lung disease,chronic obstructive pulmonary disease,BODE index

Data availability:

Keywords: lung transplantation, sildenafil, pulmonary hypertension, end-stage lung disease, chronic obstructive pulmonary disease, BODE index

Sildenafil in severe pulmonary hypertension associated with chronic obstructive pulmonary disease: A randomized controlled multicenter clinical trial.

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